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HighlightsSolute carrier family 22 member 17 (SLC22A17), which is a member of solute carrier family, is a protein encoded by the SLC22A17 gene in humans. It is also known as Lipocalin-2 receptor (LCN2) or Neutrophil gelatinase-associated lipocalin receptor (NgalR). SLC22A17 is involved in many physiological and pathological processes such as cell differentiation, apoptosis, and inflammation.
| Basic Information of SLC22A17 | |
| Protein Name | Solute carrier family 22 member 17 |
| Gene Name | SLC22A17 |
| Aliases | 24p3 receptor (24p3R), Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor (NgalR) |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q8WUG5 |
| Transmembrane Times | 11 |
| Length (aa) | 538 |
| Sequence | MASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPTRCDHVPLLATPNPAL |
SLC22A17 play a key role in iron homeostasis and transport. It is capable of binding iron-bound SLC22A17 (holo-24p3), then internalizing holo-24p3 and releasing iron, thereby increasing intracellular iron concentration and thereby inhibiting apoptosis. It is also possible to combine iron-free SLC22A17 (apo-24p3), then internalize apo-24p3 and associate it with intracellular iron cells, resulting in iron chelation and transfer of iron to the extracellular medium, thereby reducing cells. The concentration of iron inside causes apoptosis by similarity.
Fig.1 The structure of SLC22A17 Protein.
This article reveals that human lcn2-r-ntd can participate in the fine-tuning of the interaction between NGAL and its cellular receptors, or in a biochemical mechanism, enabling receptors to distinguish between apo and holo-NGAL.
The research suggests that BOCT1 and BOCT2-expressing cells do not have transport activity for a number of other SLC22 substrates.
The authors detected the localization of receptors in the vegetative ectoderm, suggesting that the endometrial SLC22A17 is involved in carrying small substances from the mother to the fetus.
These results imply that SLC22A17 regulates the secretion of pro-inflammatory cytokines in the PDAC tumor microenvironment PSC, while down-regulation of the LCN2-specific receptor SLC22A17 prevents these effects.
Clear orthological relationships of zebrafish slc22 and other vertebrate slc22 genes were established in this research. Because of their physiological and toxicological importance, slc22 members are highly conserved.
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC22A17 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
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