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HighlightsSolute carrier family 22 member 13 (SLC22A13) is a member of solute carrier family, which in humans is encoded by the SLC22A13 gene. It is also known as Organic cation transporter-like 3 (ORCTL-3). SLC22A13 is highly expressed in kidneys and to a weaker extent in brain, heart, and intestine.
| Basic Information of SLC22A13 | |
| Protein Name | Solute carrier family 22 member 13 |
| Gene Name | SLC22A13 |
| Aliases | Organic cation transporter-like 3 (ORCTL-3) |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q9Y226 |
| Transmembrane Times | 12 |
| Length (aa) | 551 |
| Sequence | MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSSPGVAFVSSTYF |
SLC22A13 is an evolutionarily conserved transport protein of plasma membranes. In humans and mice, it is mainly manifested in the kidneys. This gene encodes a member of the organic cation transport family. It is located in a gene cluster, with another family member, an organic cation transporter such as 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein acts to regulate the urine salt and is a high-affinity nicotinate exchanger in the kidneys and intestines.
Fig.1 The structure of SLC22A13 Protein.
This article provides evidence that SLC22A13 leads to apoptosis through ER stress-mediated mechanisms. ORCTL3 was detected to be down-regulated in human kidney tumors.
These findings not only link functionality to evolutionarily conservative topics, but also point to the need for a modified SLC22 classification.
The results suggest that the SLC22 family of transporters has an important influence on physiology, pharmacology and toxicology.
The authors propose that in type A cells, SLC22A13 compensates for proton withdrawal by expelling the basolateral side of anions and glutamate
The results imply that Uricosurics, diuretics, and cyclosporine A have substantial interactions with hOAT10.
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC22A13 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
