Adjuvant Optimization
Adjuvants play an important part in enhancing the immune response to the antigen. Creative Biolabs has experts in adjuvant optimization development. Our adjuvant optimization strategies can provide you with the best advice and accelerate your vaccine development program. We offer a full range of Custom Adjuvant Synthesis services including Aluminum, Oil Adjuvant, Bacterial products, ISCOMS and more, and provides PRR Ligands Scanning and Custom Adjuvant Synthesis services for vaccine adjuvantation to meet different customer's demand.
An important component of many vaccines such as those employing recombinant proteins is the adjuvant. Adjuvant is an immunological agent that added to vaccines to modify the immune response. Adjuvants enhance the ability of antigens by boosting it to give a higher amount of antibody and a longer-lasting protection, thus minimizing the amount of injected foreign material.
As a leading service provider, Creative Biolabs offers a full range of adjuvants, including:
Table 1. Classification of Adjuvants.
| Type | Adjuvant | Advantages |
| Inorganic compounds | alum, aluminum hydroxide, aluminum phosphate, calcium phosphate hydroxide |
safe well sourced |
| Oil Adjuvant | Mineral oil (paraffin oil), Food Based oil (Adjuvant 65) |
safe potent immune responses for delivery of poorly water-soluble drugs |
| Liposomes | Cationic lipids |
can deliver various antigens can co-deliver various immune potentiators |
| Bacterial products | killed bacteria Bordetella pertussis, Mycobacterium bovis, toxoids | potent immunostimulatory capacity |
| Immunostimulatory Compexes (ISCOMS) |
detergents (Quil A) IL-1 AND-2 |
composed of two veterinary products. Scalable manufacturing process in place |
Adjuvants are added to vaccines to enhance the immune response to the antigen in different ways:
- Broadening vaccine protection by extending the presence of antigen in the blood
- Improving immune response by helping absorb the antigen presenting cells antigen
- Supporting the production of cytokines
- Activating lymphocytes and macrophages
Our scientists from Creative Biolabs are committed to helping you with the best adjuvant optimization advices. Different factors should be taken into consideration when choosing the right adjuvant, including the type of antigens, the type of animal to be immunized, the route of immunization, and possible side effects. The ideal adjuvant should be capable of stimulating the desired immune response (e.g., inducing humoral or cellular immune responses based on the need for immune protection) while not causing any autoimmune response. The adjuvants should also have longer shelf life, be easily degraded by the body, and less cost. Adjuvants may produce different effects though different routes of immunization (e.g., mucosal and injection routes).
For years, Creative Biolabs has consistently and effectively supported the vaccine development industry with a unique range of products and related services. Our scientists and technicians are committed to assisting you with the adjuvant optimization process and helping you through to the later stages of vaccine development.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
