Vaccine Assessment In Vivo Assays

In vivo assays play a crucial role in the assessment of the potency and safety of human vaccines. Efficient translation from basic research to clinical therapies will depend on the availability of appropriate animal models to address every problem that arises during vaccine development. Creative Biolabs offers our customers a series of in vivo assays to enlighten the long and grueling path of vaccine development.

Animal Models in Modern Vaccine Development

Creative Biolabs offers vaccine assessment service in a variety of animal models for studying disease pathogenesis, host-pathogen interactions and protection mechanisms after vaccination, infections or disease treatment. Natural and surrogate animal models are commonly used.

• Natural disease models use specific pathogens and their native hosts to model the interactions between hosts and pathogens in the appropriate biological context. This helps to understand the immunopathogenesis, analyze the virulence factors and their roles in invasion, penetration, and toxicity as well as host’s immune responses to pathogens. In addition, such models also allow the identification of specific molecules which are often required by the pathogen for infection or subsequent disease induction, and which often represent the targets for the host's immune response.
• Surrogate models provide a useful tool for studying specific aspects of disease pathogenesis and host immune response. Surrogate models use species that can only be infected with the pathogen of interested under experimental conditions. Therefore, compromises often have to be made, such as higher infection doses or artificial routes of infection. In most cases, mice are chosen because of their consistent genetic background, being easy to operate and cost-effective.
• We also provide assessment service in animal models to analyze specific aspects of the immune response such as the role of specific immune compartments or individual cell populations, the development of immune organs, the transport of immune cells after infection or vaccination, and various aspects of vaccines including mucosal or topical application.
• We offer service to explore various aspects of vaccine formulation and delivery, including route of administration, targeting to specific receptors and inducing mucosal immunity to the body. The development of effective vaccine adjuvants and delivery system optimization is crucial for achieving immune-mediated protection against infection. In Creative Biolabs, surgical animal models have been developed that specifically facilitate the analysis of formulation and delivery.
• The effectiveness of vaccine immunization of infants or the elderly can vary widely. Creative Biolabs use natural disease models including E. coli and rotavirus infected pigs and calves to establish the concept of a maternal vaccine as an effective strategy to reduce the risk of neonate’s infection.

On the other hand, to reduce the number of animals needed and the suffering involved in specific vaccine tests, Creative Biolabs offers non-animal assessment (Vaccine Assessment In Vitro Assays) to meet different customer’s demands. Animal models allow the assessment of key issues in vaccine development such as vaccine delivery, immunopathogenesis and the host’s immune response to vaccination. Thus, the use of appropriate animal models is still very important for the development of human vaccines. As one of the most highly respected vaccine testing laboratories in the world, Creative Biolabs is committed to help you through the assessment stages of development with our excellent preclinical in vivo assays.

Reference

1. Gerdts V; et al. Use of animal models in the development of human vaccines. Future Microbiol. 2007, 2(6): 667-75.

All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.