The Microbial Tests of Vaccines

One of the most important effects of microorganisms on humans is to cause infectious diseases. Great advances have been made in the use of vaccines for disease prevention and intervention, but microbial infections continue to occur in vaccines. Therefore, it is very important to establish a standard vaccine microorganism detection platform. Creative Biolabs is a world leader in the field of vaccine analytical development. With our extensive experience and advanced platform, we are therefore confident in offering the best development services for the microbial test of vaccines. We guarantee the finest results for our customers all over the world.

The Culturing Process of Microbial Tests

Fig.1 The Culturing Process of Microbial Tests.

The Methods of Vaccine Microbial Tests

There are many ways to detect the number of microbes in a vaccine. One is blood cell counting plate method. The blood cell count plate is a thick glass plate with a special structure scale and thickness. There are four furrows and two ridges on the glass plate, a short transverse groove and two platforms in the center. The table of the two ridges is 0.1 mm higher than the surface of the two platforms. By observing with oil mirror, the number of microorganisms in a certain large cell can be calculated, and the number of bacteria contained in 1 ml of bacteria liquid can be calculated. This method is simple, intuitive and quick, but only counts the spores produced by microorganism or filamentous microorganism suitable for single cell state, and the result is the total number of bacteria including dead cells.

Another is ATP bioluminescence assay. ATP is an active molecular in all biological cells, and its three phosphate roots are linked to adenosine molecules by a high energy bond, which releases energy when the ATP is decomposed. When the bacteria release ATP, they can use the biochemical square to measure the ATP content. This method allows results to be achieved within minutes and significantly reduces detection time.

The Development of Vaccine Microbial Test Platforms

Creative Biolabs has developed various microbiological detection instruments and equipment by combining traditional microbiological detection principles and different detection methods, which are gradually widely used in the field of medical microbiological detection and scientific research. Such as:

1. The combination of anti-interference culture medium and rapid detection technology of microorganism quantity solves the problem that cannot be solved by traditional microorganism detection methods, laying a solid foundation for establishing a complete set of anti-interference microorganism detection system. The anti-interference microbial culture medium, new biochemical identification tube, microorganism counting card, and the environmental quality detection kits can be conveniently used for multiple tests.

2. BACTOMETER automatic of the total number of bacteria and bacteria detection system monitoring results can be obtained within a few hours and sample color and optical characteristics will not affect the readings, the yeast, and mold testing are highly sensitive because of using the same resistance KangFa (IMPEDANCE TECHNOLOGY) assay. The bottom of this system has a pair of stainless steel electrode. The determination of the IMPEDANCE changes due to microbial growth.

Our Strategies of The Vaccines Microbial Tests

The Microbial culture – Creative Biolabs

Our Microbial Tests technology for traditional and new vaccines are developed by the combination of related technologies of various disciplines. Up to now, no single technology can be used to undertake the whole process of tests. Creative Biolabs innovative microbial tests process is often composed of several new technologies and the advantages of the original technology. For example, when microorganisms grow, large molecular nutrients in the culture medium can be converted into active small molecules through metabolism. This weak change can be tested by resistance method so that the existence and quantity of microorganisms can be monitored more rapidly than that of traditional plate method.

  • The simple and automatic detection platform
  • The high cost performance
  • The rapid and accurate detection system

Creative Biolabs is a leader in the field of vaccine development and has focused on the vaccines analytical development and qualification services for years. We have experienced experts and advanced platforms that are able to provide excellent services. If you are interested in our services, please contact us for more details.


Our services are for research use only. We do not provide services directly to individuals.


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