Vaccines for Peanut Allergy
Among food allergies, peanut has attracted the most research attention because it has a significant effect on the quality of life of sufferers and their families. With the in-depth study of immunotherapy for allergic reactions, it is proved that the vaccine can induce a complete immune response against peanut allergy, and has important application value in the control of allergic diseases. Creative Biolabs is a world leader in the field of vaccine development. With our extensive experience and advanced platform, we are therefore confident in offering the best vaccine development services for allergic disease.
Background of Peanut Allergy
Peanut allergy can be a fatal food-related allergy that can lead to life-threatening allergic reactions due to minor exposures. Peanut allergy was once rare, but it is now the most common cause of fatal food-allergic reactions. In the past decade, the prevalence has steadily increased, mainly in the Western world, which currently affects 1-2% of children. Peanut allergy poses a significant burden on the quality of life of sufferers and their families due to dietary and social restrictions, but mainly result from the fear of accidental peanut ingestion. Currently, the only available treatment is strict avoidance of all peanut products and timely treatment of accidental ingestions with antihistamines and self-injectable epinephrine. In recent years, great progress has been made in elucidating the immunologic response to peanut, characterizing specific peanut allergens, and in developing alternative therapies for peanut allergy.
LAMP Technology Platform
LAMP technology is a next-generation DNA vaccine platform designed to induce an immune response against a specific protein by injecting the DNA encoding the protein rather than the protein itself. It contains a short DNA sequence encoding a lysosomal-associated membrane protein (LAMP), which allows DNA vaccines based on the LAMP platform to utilize the body's natural biochemistry to produce a more complete immune response than conventional DNA vaccines. The ability to activate a complete immune response confers potential for LAMP technology in a variety of diseases, such as allergic diseases and cancer immunotherapy.
Peanut Allergy Vaccines Based on LAMP Platform
Recent developments have highlighted the use of immunotherapy, which has shown promise as an active form of treatment and may provide disease-modifying therapies for peanut allergy. So far, efforts have been made to develop vaccines for peanut allergy, which have shown good efficacy in achieving desensitization to peanut with a good safety profile. The ability of the DNA vaccine to induce Th1 and Th2 immune responses and its ability to modulate immune responses at multiple levels make it a promising preventive and therapeutic measure for allergic diseases. Conventional DNA vaccines primarily elicit cytotoxic T cell immune responses, whereas vaccines developed using LAMP can elicit a more complete immune response against peanut allergy, including antibody production, cytokine release, and critical immune memory, which makes it a huge potential for the control of allergic reactions.
The Advantages of DNA Vaccines
The DNA vaccine is a recombinant which is composed of the exogenous gene encoding a certain protein and a certain vector, which can be directly introduced into animal cells to induce the immune response. Compared with other types of vaccines, it has the following advantages:
- Easy to operate and mass production
- Higher security and very low side reaction
- Inducing a lasting immune response
- Very low cost
With appropriate technical equipment and years of experience in vaccine development services, Creative Biolabs has been dedicated to the development of allergic disease vaccines for years. We offer high-quality customized services according to your needs in a highly productive and cost-effective way. If you want to know more, please feel free to contact us.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
