Basal Cell Carcinoma Vaccines

Creative Biolabs is a world leader in the field of cancer vaccine development. With our extensive experience and advanced platform, we are therefore confident in offering the best services for vaccine development against basal cell carcinoma and guarantee the finest results for our customers all over the world.

Basal Cell Carcinoma

Basal cell carcinoma (BCC), also known as basal-cell cancer, is the most common type of skin cancer which accounts for 80% to 90% of all primary skin cancers. BCC is an abnormal, uncontrolled growth or injury that occurs in the basal cells of the skin that line the deepest layer of the epidermis. The clinical appearance of BCCs is characterized by their translucency, ulceration, telangiectasias, and the presence of a rolled border. However, these features vary by clinical subtype, which includes nodular, pigmented, morphea form, and superficial BCCs, as well as fibroepithelioma of Pinkus. Basal cell carcinoma grows slowly and can damage the surrounding tissue, but is unlikely to spread far away or cause death. Only in extremely rare cases can it spread to other parts of the body and endanger life.

Risk factors include lighter skin, exposure to ultraviolet light, long-term exposure to arsenic, radiation therapy and poor immune system function. The diagnosis is usually based on a skin test and confirmed by a tissue biopsy. Treatment is usually by surgery while other options may include laser surgery, cold, topical chemotherapy or use of imiquimod. Chemotherapy or targeted therapy can be used in the rare case of distant spread.

Basal Cell Carcinoma - Creative Biolabs

HPV Vaccines for Basal Cell Carcinoma

Papilloma virus (PV) infects keratinocytes of the skin and mucosa of different vertebrate species, including humans. Human papillomavirus (HPV) is a nonenveloped, double-stranded DNA virus that infects squamous epithelial cells. To date, more than 170 human papillomavirus (HPV) types are known and are associated with different clinical manifestations. Genital HPVs cause a variety of pathologies, ranging from benign warts (for low-risk HPV types) to different malignancies (for high-risk types). In addition to cervical cancer, a wide range of skin HPV types are associated with different skin cancer including basal cell carcinoma.

It is suspected that the HPVs from the β genus play a role in the development of non-melanoma skin cancer (NMSC). The NMSC includes basal cell carcinoma (approximately 80% of cases), Cutaneous Squamous Cell Carcinoma (SCC, approximately 20% of cases), and other less frequent entities of NMSC. Current researches show cumulative evidence that some skin HPV infections may be a factor in the development of BCC. [1] Because there are already vaccines against some of the sexually transmitted HPVs, it would be easy to develop a vaccine against skin HPVs if it is sure that they cause disease.

Creative Biolabs is a leader in the field of vaccine development and has focused on the cancer vaccines for years. We have experts who are able to help you with the basal cell carcinoma vaccine development. If you are interested in our services, please contact us for more details.

Reference

  • Vinzón, SE. (2015). “HPV vaccination for prevention of skin cancer.” Hum Vaccin Immunother 1 (2), 353-357.

Our services are for research use only. We do not provide services directly to individuals.


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