Custom Adjuvant Synthesis
Modern vaccines based on homogeneous subunit antigens are highly purified, which offer significant advantages over classical vaccines based on whole pathogens, enabling more precise targeting of the immune response and improved safety. However, such subunit vaccines are poorly immunogenic proteins, including feeble, short-lived immune responses. Immunoadjuvants are used to potentiate the activity of modern subunit vaccines that are based on molecular antigens. Creative Biolabs is a world leader in vaccine services and provide adjuvants for vaccines to meet different customer's demand. We offer a full range of Custom Adjuvant Synthesis services including Aluminum, Oil Adjuvant, Bacterial products, ISCOMS and more.
Adjuvants are included in sub-unit or recombinant vaccines to enhance the potency of poorly immunogenic antigens. Adjuvant development is as complex as it is a multidisciplinary intersection of formulation science, immunology, toxicology, and biology. The need for the development of safe and effective vaccine adjuvant has provided an impetus for the systematic exploration of a variety of innate immune stimuli, including small-molecule agonists of TLR2, TLR7, TLR8, nucleotide oligomerization domain 1 (NOD1), as well as C-C chemokine receptor type 1 (CCR1).
Classification of Adjuvants
As a leading service provider, Creative Biolabs offers a full range of Custom Adjuvant Synthesis services, including:
Table 1. Classification of Adjuvants.
| Type | Adjuvant | Advantages |
|---|---|---|
| Inorganic Compounds | alum, aluminum hydroxide, aluminum phosphate, calcium phosphate hydroxide |
safe well sourced |
| Oil Adjuvant | Mineral oil (paraffin oil), Food Based oil (Adjuvant 65) |
safe potent immune responses for delivery of poorly water-soluble drugs |
| Liposomes | Cationic lipids |
can deliver various antigens can co-deliver various immune potentiators |
| Bacterial Products | Killed bacteria Bordetella pertussis, Mycobacterium bovis, toxoids | potent immunostimulatory capacity |
| Immunostimulatory Complexes (ISCOMS) |
Detergents (Quil A) IL-1 AND-2 |
composed of two veterinary products Scalable manufacturing process in place |
Aluminium Based Minerals
The majority of currently available vaccines contain a single adjuvant, “alum” (s mixture of aluminum phosphate and aluminum hydroxide), which was introduced by Alexander Glenny in 1926. Although aluminum salts have been in widespread use and have a good safety record, they are weak adjuvants for antibody induction and induce a T helper-2 (Th2) -skewed, rather than a T helper-1 (Th1) response, an attribute that has been implicated in the rapidly waning humoral responses to re-emergence of pertussis in the USA and elsewhere in the world. Thus, more effective adjuvants are required to realize the full potential of subunit vaccines.
Oil-Based Emulsions
Saponins, which are steroids or triterpene glycosides found in many wild and cultivated crops, are popular immune stimulants for inactivated vaccines. Saponins-based adjuvants have the unique ability to stimulate cellular immunity and enhance antibody production. Ginseng, Astragalus, notoginseng and other herbs have gained attention as candidates for plant derived saponins.
Bacterial Products
Bacterial products are considered as a good source of immune adjuvants because of their potent immunostimulatory capacity. Bacterial flagellin is a potent adjuvant to CD4+ T cells in vivo. Heat shock proteins (HSPs) are highly conserved proteins whose function may play a key role in the integration of innate immunity and adaptive immunity. [1]
In terms of the extensive experience in adjuvant development, Creative Biolabs will offer our clients a series of Adjuvant Synthesis services with the best quality and most competitive price. Please contact us for more details.
Reference
- Aiyer Harini; et al. An Overview of Immunologic Adjuvants. J Vaccines Vaccin. 2013, 4(1).
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
