Cell Based Vaccines

Equipped with world-leading technology platforms and professional scientists, Creative Biolabs offers all kinds of vaccine development services including cell based vaccines. Cell based vaccine is a vaccine developed from mammalian cell lines rather than embryonic chicken eggs. Cell culture techniques are used as a complementary and alternative platform for current egg-based strategies. Potential applications in the development of viral vaccines, particularly influenza vaccine, have been extensively studied in recent years.

Cell Based Vaccines

Advantages of Cell Lines

Most vaccine manufacturers today grow influenza virus in fertilized eggs, which originated in the 1930s. In the past, FDA required that egg-isolated candidate vaccine viruses be used in the production of flu vaccine. However, over the past decade, the US government has invested billions of dollars to develop new eggless manufacturing technologies in order to produce more vaccines more quickly. On August 31, 2016, FDA approved the use of cell-isolated candidate vaccine viruses in the production of Flucelvax.

Cell culture technology is more flexible than the traditional technology, which relies upon adequate supply of eggs. Traditional methods usually take about five to six months from identifying the strain until the first dose of the vaccine is produced. Compared with the traditional egg-based manufacturing techniques, the main advantage of the new production process is that manufacturers do not have to wait for eggs to be delivered or worry about supply shortages. The cells used to manufacture vaccines are kept frozen and “banked”, which assures an adequate supply of cells available for vaccine production. This increase in speed is crucial during the pandemic and can save tens of thousands of lives. In addition, when the production schedule is tight, it can also provide a first-market advantage for the influenza vaccine manufacturers.

  • Be able to rapidly produce vaccine supplies during an impending pandemic.
  • Avoid egg-based allergy reactions.
  • Can be grown in synthetic media avoiding animal serum, which prevents the spread of transmissible spongiform encephalopathies.
Cell Based Vaccines

How Is Cell Based Vaccine Made?

The cell lines are placed in a large stainless-steel bucket that allows them to mature. One of the influenza strains, which loses the ability to spread the virus through the purification process, is introduced into the bucket. The virus then goes through an extra purification step and is finally ready for mass use.

Our Services

Cell culture technology has been widely used to produce other U.S.-licensed vaccines, including vaccines against polio, rotavirus, hepatitis, chickenpox, smallpox, and rubella. The major drawback is cost. The cell based vaccines are much more expensive to produce per dose than egg based. But the benefits for development of cell based vaccines are quantifiable and visible. As a pioneer and the undisrupted global leader in vaccine technology, Creative Biolabs is always dedicated to assisting our clients with the most satisfactory vaccine related services. If you are interested in cell based vaccines, please feel free to contact us for more details.

All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

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All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

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