Autoimmune Disease Vaccines

Creative Biolabs is a well-equipped manufacturer of vaccines with a broad range of vaccine development services including Autoimmune Disease Vaccines. Preventive vaccines are for healthy people and prevent them from getting sick, which has been a great success. In addition to preventive vaccines, therapeutic vaccines are becoming increasingly important, especially as life expectancy increases. Vaccines for diseases such as AIDS, cancer, tuberculosis, hepatitis, Alzheimer's disease, and mad cow disease have not yet reached the stage of successful use. However, the vaccines in the field of autoimmune diseases have made significant progress. Similar to prophylactic vaccines for the prevention of infectious diseases, therapeutic vaccines against autoimmune diseases are based on similarity to the putative causes of disease.

Autoimmune Disease

Autoimmune diseases are disorders caused by abnormal immune responses in normal body parts. Some common diseases that are generally considered autoimmune include psoriasis, Systemic lupus erythematosus, multiple sclerosis, Graves' disease, celiac disease, Ankylosing spondylitis (AS), inflammatory bowel disease, diabetes mellitus type 1, and Rheumatoid arthritis (RA). There are at least 80 types of autoimmune diseases. Almost any body parts can be involved. The etiology and triggering mechanism of autoimmune diseases are still unclear. Some autoimmune diseases such as lupus run in families, and some cases may be triggered by infection or other environmental factors.

The main pathogenic mechanisms of autoimmune disease are the following:

Molecular mimicry by which viral or bacterial agents trigger an immune response against autoantigens: the susceptible host is infected by an agent carrying antigens immunologically similar to the host antigens but trigger a different immune response when presented to T cells. As a result, the tolerance to autoantigens breaks down, and the pathogen-specific immune response causes tissue damage;
Bystander activation by which microbial agents release sequestered self-antigens from host tissue that activate antigen-presenting cells (APCs) and dormant autoreactive T-helper cells. These autoreactive T cells, along with macrophages, secrete cytokines, and an additive effect results in local inflammation and the recruitment of additional T-helper cells.

Vaccines for Autoimmune Disease

The currently available therapies for destructive immune responses in autoimmune diseases are based on non-specific agents systemically suppressing the function of many immune effector cells. However, this indiscriminate immunosuppression often leads to serious, sometimes even life-threatening side effects. Therefore, more specific treatments with lower toxicity and longer-term solutions are required. Vaccine plays an important role in modern medicine vaccination and is one of the most effective strategies available to fight against diseases. Because they provide long-term specific protective immune responses, vaccines have great potential in the prevention of autoimmune diseases. Current advances in the development of vaccines for autoimmune diseases are primarily based on DNA, altered peptide ligands, T cells, and T cells receptors.

Autoimmune Disease Vaccines

DNA Based Vaccines

DNA vaccines have high priority because they usually have lower immunogenicity compared to other conventional vaccine types. DNA vaccine encoding autoantigen of autoimmune disease is not only safe and well tolerated but also stable, inexpensive and easy to scale up. More importantly, DNA vaccination can be easily improved. A DNA vaccine consisting of some cytokine genes and genes encoding self-peptide proteins can significantly enhance the immune effect. This indicates that the DNA vaccine plays an important role in regulating the immune system and may have clinical application value in the treatment of autoimmune diseases.

Peptide-based Vaccines

One of the most accurate selections of vaccine components exists in epitope-based peptide vaccines, where the peptide can mimic naturally processed epitopes to act as tolerogens in autoimmune diseases. Altered peptide ligands (APLs) are analogs of immunogenic epitopes that are modified by the introduction of one to several amino acid substitutions while retaining MHC binding properties. APLs induce antigen-specific Th2 T cell responses that may inhibit disease activity, therefore, have been designed as a vaccine for the prevention of autoimmune diseases.

T Cell Vaccines

The T cell vaccines for the treatment of autoimmune diseases is to generate an immune response against the pathogenic autoreactive T cells by isolating autoantigen-specific T cell clones from the intended recipients and after attenuation / inactivation, re-injecting the isolated cells as a vaccine to stimulate endogenous regulatory circuits. T cell vaccines are safe, effective, well-tolerated, have no side effects and could be applied despite the autoantigens are unknown.

T Cell Receptor Peptide Vaccines

The synthetic T cell receptor (TCR) peptide vaccines are typically derived from the hypervariable region of the TCR molecule or idiotypic determinants of CDR3 / CDR2. They could induce specific regulatory immunity and modulate the activity of autoreactive T cells in several autoimmune diseases, leading to clinical benefit.

Our Services for Autoimmune Disease Vaccines

With years of experience in vaccine development and a state-of-the-art technology platform, Creative Biolabs is committed to providing the best-customized solutions and protocols for the development of autoimmune disease vaccines. We offer vaccine development services for the following autoimmune diseases:

Creative Biolabs is a leader in the field of vaccine development and has focused on vaccine development services for years. We have experienced experts and advanced platforms that are able to provide excellent vaccine services for autoimmune disease. If you would like to know more, please feel free to contact us.

All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.