Formulation Development

The modern-day vaccines made using chemical, biosynthetic and rDNA techniques are generally less immunogenic than older style vaccines made in response to proteins, carbohydrates, complex lipids and nucleic acids isolated from natural sources. Thus, vaccines sometimes need a molecule in conjugation to augment its immune response. One can improve the quality of vaccine production by co-administering these with an Adjuvant or immunomodulators with modified Delivery System, such as Nanoparticle, Liposome and immune stimulating complexes (ISCOMs). Creative Biolabs is an expert who provide remarkable vaccine formulation related services including Formulation Optimization, Adjuvant Selection and Delivery System Selection.

Adjuvant Selection

Adjuvant selection is greatly dependent on the antigen, the species to be vaccinated, the route of administration and the likelihood of side effects. Ideally, adjuvants should be effective and safe, yet several other characteristics for successful adjuvants must be considered as well, including:

  • Promote an appropriate immune response;
  • Do not induce immune responses against themselves;
  • Be stable with long shelf life;
  • Bio-degradable;
  • Cheap to produce.
Formulation Development

Adjuvants are used to increase the effect of a vaccine by stimulating the immune system to ensure a high quantity/quality, memory-enhanced antibody response. The second reason for incorporating an adjuvant into a vaccine is to guide the type of adaptive response to produce the most effective forms of immunity for each specific pathogen. For vaccines currently under development, adjuvants are increasingly used to promote types of immunity not effectively generated by the non-adjuvanted antigens [1].

Delivery System Selection

Formulation Development

The adjuvant and the antigen should be together at the same site. Several formulations and delivery systems have been developed to solve this problem, including nanoparticle, liposome, immune stimulating complexes (ISCOMs), emulsion and microspheres. A successful delivery system should have the following properties:

• Protect antigen from degradation
• Sustain release of antigen
• Intracellular delivery of antigen contributing to cytotoxic T-cell stimulation and targeting at APCs

Adjuvants can improve the effectiveness of vaccines by promoting the immune response with a longer duration, increase the low response rate of some individuals and reduce the cost of vaccination programs by reducing the quantity of antigen needed. Delivery systems concentrate the adjuvant and antigens in repetitive patterns, target vaccine antigens to APCs and help co-localize antigens and immunopotentiators. Together, adjuvants and delivery systems can enhance body specific and active immune reaction.

In terms of the extensive experience in Formulation Optimization, Creative Biolabs is proud to offer our clients a series of Adjuvant Selection and Delivery System Selection services with the best quality and most competitive price.

Reference

1. Mohan T; et al. Novel adjuvants & delivery vehicles for vaccines development: a road ahead. Indian J Med Res. 2013, 138(5): 779-95.


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