Vector Based Vaccines
Creative Biolabs is a world leader in the field of cancer vaccine development. With our extensive experience and advanced platform, we are therefore confident in offering the best development services for vector-based cancer vaccines. We guarantee the finest results for our customers all over the world.
The advantages of vector-based vaccines include 1) Multiple delivery of TAAs at one time; 2) Vector itself is immunogenic, boosting the overall immune response; 3) Speedy and easy production. Besides virus vector, unharmful bacteria, yeast cells or other structures can also be used as vector to deliver the TAAs into the body.
Viral Vectors for Cancer Therapy
- Adenovirus Based Vaccines for Cancer: Adenoviruses have long been used as a gene therapy vehicle for the treatment of cancer and other diseases. Several approaches using adenoviruses encoding TAAs have been used in clinical trials.
- Poxvirus Based Vaccines for Cancer: Poxviruses have been widely used as vaccine vectors for cancer therapy. In the clinic, poxviruses have been shown to be safe and effective at inducing immune responses. While vaccinia virus is the most frequently used vector in the poxvirus family, other viruses such as canarypox and fowlpox have also had success in the clinic. The canarypox vector ALVAC has been well tolerated in several clinical trials and has been shown to increase antigen-specific T cell response.
- Alphavirus Based Vaccines for Cancer: Numerous phase I trials have been conducted using viruses other than poxviruses as the immunotherapy delivery system. Alphaviruses, like avipox viruses, are also desirable vectors because infected hosts do not develop neutralizing antibodies to the vectors, allowing for multiple injections.
- Lentivirus Based Vaccines for Cancer: Lentiviral vectors (LVs) have been identified as potentially more effective and safer alternative delivery vehicles. LVs are now in use in clinical trials for many different types of inherited and acquired disorders, including cancer.
- NDV Based Vaccines for Cancer: The paramyxovirus Newcastle disease virus (NDV) has been more thoroughly explored as a cancer vaccine. NDV has been used in the clinic directly as a vaccine and also as an oncolysate vaccine, where tumor cells are infected with NDV and then introduced back into the patient as an autologous tumor cell vaccine. PV701, an oncolytic strain of NDV, has been used in phase I/II clinical trials with no signs of serious side effects.
- HSV-1 Based Vaccines for Cancer: Many replication-incompetent HSV-1-based vectors have also been used either as potential anti-herpes vaccines, as well as vaccine vectors for other pathogens in murine and simian models.
- Measles Virus Based Vaccines for Cancer: Oncolytic measles viruses have shown great potential as cancer therapeutics. Recent advances in genetic engineering of measles virus allow insertion of therapeutic and diagnostic transgenes as well as complete retargeting of measles virus. These strategies resulted in the generation of recombinant measles viruses allowing non-invasive monitoring of viral replication and viral spread.
- Arenavirus Based Vaccines for Cancer: Arenavirus is gaining increasing attention in being used as vaccine vector for that they are relatively easily genetically engineered to accommodate multiple foreign genes of interest and with a high expression level. In addition, there is no pre-existing anti-vector immunity risk of using arenavirus as vector which is a bottleneck that limits the use of viral vectors as vaccines.
Bacterial Vectors for Cancer Vaccines
Recombinant vector systems based on viruses or bacteria are a very attractive tool since they induce a powerful innate immune response as well as cellular immunity. Thus, passenger antigens are presented in an optimized cytokine environment to the immune system. A disadvantage of viral vectors is the generation of neutralizing antibodies against the vector backbone, which prevent further boosting steps. Intracellular bacteria can potentially address some of the shortcomings of viruses without giving up the intrinsic advantages of live vector systems.
Fungal Vectors for Cancer Vaccines
Creative Biolabs is a leader in the field of vaccine development and has focused on the cancer vaccines for years. We have experienced experts and advanced platforms that are able to provide excellent services. If you are interested in our services, please contact us for more details.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
