Adjuvant Selection

Creative Biolabs is a world leader in vaccine services and provide adjuvants for vaccines to meet different customer's demand. We offer a full range of Custom Adjuvant Synthesis services including Aluminum, Oil Adjuvant, Bacterial products, ISCOMS and more. Adjuvants play an important part in enhancing the immune response to the antigen. Creative Biolabs’ adjuvant can enhance the ability of antigens while reducing the amount of antigen needed.

What Is An Adjuvant?

Adjuvant is an immunological agent that added to vaccines to modify the immune response. Adjuvants enhance the ability of antigens by boosting it to give a higher amount of antibody and a longer-lasting protection, thus minimizing the amount of injected foreign material.

Mechanisms of Adjuvants

Adjuvants are added to vaccines to enhance the immune response to the antigen in different ways:

Broadening vaccine protection by extending the presence of antigen in the blood
Improving immune response by helping absorb the antigen presenting cells antigen
Supporting the production of cytokines
Activating lymphocytes and macrophages

Adjuvants can act in various ways in presenting an antigen to the immune system to improve routing and adaptive immune responses to antigens. The reaction is mediated by B and T cells, two primary types of lymphocytes. Adjuvants apply their effects through different mechanisms. Some adjuvants, such as alum (the first aluminum salt used as an adjuvant), apply their effects as delivery systems by generating depots that trap antigens at the injection site, providing a slow release that continues to stimulate the immune system. Adjuvants can also extend the supply of a vaccine by reducing the amount of antigen needed.

The immune response to vaccination with and without adjuvant.

Fig. 1 The immune response to vaccination with and without adjuvant ^[1]

Classification of Adjuvants

As a leading service provider, Creative Biolabs offers a full range of Custom Adjuvant Synthesis services, including:

Table 1. Classification of Adjuvants

Type	Adjuvant	Advantages
Inorganic Compounds	alum, aluminum hydroxide, aluminum phosphate, calcium phosphate hydroxide	safe well sourced
Oil Adjuvant	Mineral oil (paraffin oil), Food Based oil (Adjuvant 65)	safe potent immune responses for delivery of poorly water-soluble drugs
Liposomes	Cationic lipids	can deliver various antigens. can co-deliver various immune potentiators.
Bacterial Products	Killed bacteria Bordetella pertussis, Mycobacterium bovis, toxoids	potent immunostimulatory capacity
Immunostimulatory Compexes (ISCOMS)	Detergents (Quil A) IL-1 AND-2	composed of two veterinary products. Scalable manufacturing process in place

PRR Ligands Scanning

Pattern recognition receptors (PRRs) are proteins expressed by cells of the innate immune system to identify two classes of molecules: pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Creative Biolabs provides PRR Ligands Scanning services to identify potent inhibitors or activators of infectious diseases-related innate immune signaling pathways.

Features

Personalized services: We provide various screening parameters to meet our customers’ requirements.
Quickly: Short screening turnaround time
Competitive price with the best quality

Creative Biolabs provides our clients a wide range of vaccine adjuvants synthesis services. Our scientists are confident in offering the best services and products upon request.