Excipient Screening & Selection

Creative Biolabs is experienced in formulation development of vaccines including validated analytical assays and tools. We have established a comprehensive database and algorithm-based formulation platform which can help you explore the best formulations with high success rate and short timeline.

Vaccine Excipients

As more and more vaccines are developed, stabilization in processing and storage poses a major challenge to the pharmaceutical industry. Vaccines are inherently unstable and susceptible to degradation by several physical and chemical degradation mechanisms. Therefore, various excipients are required during processing and storage to stabilize biological agents and vaccines. Excipients are an integral part of vaccine candidates and play an essential role in the formulation development of vaccines. New therapies and powerful pharmaceutical products can be developed by selecting and using the right excipients. For proteins and vaccines, excipients have clear functional roles, including:

Vaccine Excipients - Creative Biolabs
  • Enhancing the solubility of the active substance
  • Extending shelf life
  • Maintaining proper pH and tension
  • Maintaining the preferred stable conformation of the protein or vaccine
  • Preventing aggregation or degradation of active substances
  • Fillers, antioxidants or preservatives

Some commonly used pharmaceutical excipients in biologic and vaccine formulations including but not limited to:

Buffers Acetate, Succinate, Citrate, Histidine, Phosphate, Tris
Amino acids Arginine, Aspartic acid, Glutamic acid, Lysine, Proline, Glycine, Histidine, Methionine
Stabilizer/Bulking Agents Lactose, Trehalose, Dextrose, Sucrose, Sorbitol, Glycerol, Albumin, Gelatin, Mannitol, and Dextran
Surfactants Tween 20, Tween 80, Pluronic F68
Antimicrobial/Preservatives Benzyl alcohol, m-cresol, phenol, 2-phenoxyethanol
Metal ions/Chelators Ca²⁺, Zn²⁺, EDTA
Cyclodextrin based Hydroxypropyl β-cyclodextrin
Others Polyanions, Salts

Creative Biolabs’ Service Process

Vaccine Formulation Optimization – Creative Biolabs

Formulation technology platform of Creative Biolabs is based on a library of up to hundreds of different, regulatory well-known excipients. Our scientists have a comprehensive understanding of vaccine excipients and are sure to find the best solution for your vaccine formulation. Please do not hesitate to contact us for more details or send us an inquiry directly.

All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

Online Inquiry

All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

*E-mail Address:
*Products or Services Interested:
Project Description:





Follow us on

facebook   twitter   linked   blog

Shopping Basket