Bacterial Vaccines

Bacterial Vaccines Creative Biolabs can offer high-quality Bacterial Vaccines for use in bacterial diseases. Bacterial Vaccines contain attenuated or killed bacteria that activate the immune system. For Bacterial Vaccines, a pathogen strain is cultured and inactivated to produce a “whole-cell” vaccine (e.g., Bordetella pertussiss), an attenuated bacterium is used (BCG), or pathogen bacterial strains is cultured to produce inactivated and purified toxins or virulence factors (Clostridium tetani, Corynebacterium diphtheriae, B. pertussis).

Bacterial diseases can be prevented by using vaccination that induce active immunity. Active immunity can be induced by vaccines prepared from bacteria or their products. Table 1 presents a summary of the types of current bacterial vaccines.

Table 1. Current Bacterial Vaccines.

Usage Bacterium Disease Antigen
Common usage Corynebacterium diphtheriae Diphtheria Toxoid
Clostridium tetani Tetanus Toxoid
Bordetella pertussis Whooping cough Acellular (purified proteins) or killed organisms
Haemophilus influenzae Meningitis Capsular polysaccharide conjugated to carrier protein
Streptococcus pneumoniae Pneumonia Capsular polysaccharide or capsular polysaccharide conjugated to carrier protein
Neisseria meningitidis Meningitis Capsular polysaccharide or capsular polysaccharide conjugated to a carrier protein
Special situations Salmonella typhi Typhoid fever Live organisms or capsular polysaccharide
Vibrio cholerae Cholera Killed organisms
Yersinia pestis Plague Killed organisms
Bacillus anthracis Anthrax Partially purified proteins
Mycobacterium bovis (BCG) Tuberculosis Live organisms
Francisella tularensis Tularemia Live organisms
Rickettsia prowazekii Typhus Killed organisms
Coxiella burnetii Q fever Killed organisms

Bacterial vaccines are composed of (1) whole bacteria (either killed or live, attenuated), bacterial capsular polysaccharides, toxoids, or (2) purified proteins isolated from bacteria.

Killed Bacterial Vaccines

The vaccines against cholera, plague, typhus, and Q fever contain whole killed bacteria. These vaccines are used only to protect those likely to be exposed.

Live, Attenuated Bacterial Vaccines

The BCG vaccine against tuberculosis contains live, attenuated Mycobacterium bovis and is used in countries where the disease is endemic. One of the vaccines against typhoid fever contains live, attenuated S. typhi.

Capsular Polysaccharide Vaccines

Vaccines containing capsular polysaccharide as the immunogen are directed against Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and Salmonella typhi. The capsular polysaccharide in the pneumococcal vaccine, the meningococcal vaccine, and the H. influenzae vaccine is conjugated to a carrier protein to enhance the antibody response.

Toxoid Vaccines

Two vaccines contain toxoids as the immunogen, the vaccines against diphtheria and tetanus. A toxoid is an inactivated toxin that has lost its ability to cause disease but has retained its immunogenicity. (The pertussis vaccine also contains toxoid but contains other bacterial proteins as well.)

Purified Protein Vaccines

Two vaccines contain purified bacterial proteins as the immunogen. The most commonly used is the acellular pertussis vaccine, which in combination with diphtheria and tetanus toxoids is recommended for all children. The vaccine against anthrax also contains purified proteins but is recommended only for individuals who are likely to be exposed to the organism.

Bacterial Vaccines

Creative Biolabs is a world leader in vaccine services and provides different kinds of vaccines to meet different customer's demand. We offer a full range of Bacterial Vaccines including killed or live bacterial vaccines, Capsular Polysaccharide Vaccines, Toxoid Vaccines, and Purified Protein Vaccines. Welcome enquiry!

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