Plant-based Vaccines

Creative Biolabs is ahead of the world in the field of plant-based vaccine development. With years of expertise, we offer various highly customized services for plant-based vaccines development.

Plant-based Vaccines - Creative Biolabs

Plant-based Vaccines

Problems about unavailability of vaccines for the treatment of severe diseases have driven worldwide attention towards production of safer, easier, and more effective vaccines, which initiates the development of plant-based vaccines. Conventional vaccine production methods include egg-based vaccines, cell-based vaccines and investigational-manufacturing systems which the plant-based vaccines belong to. Egg-based vaccines have a history over 60 years and the method requires the injection of virus particles into eggs and an extra incubation for virus replication. The procedure involving selection for appropriate virus strains to be replicated in eggs, complicated purification process in downstream antigen expression and a demand for huge number of eggs makes vaccine production far more time-consuming. For cell-based vaccines, requirements for costly fermentation facilities also limit its scale-up production.

Plant-based vaccines are a kind of recombinant vaccines that introduce antigens against particular pathogens into the selected plant. By far, scientists have developed over 200 proteins expressed in plants. These encouraging results demonstrate a brighter future for plant-based vaccines. Hiatt and his colleagues firstly made attempt to produce vaccines using plants since 1989. National Institute of Allergic and Infectious Diseases (NIAID) certified that plant-based vaccines could induce sufficient immunogenicity in inoculated individuals in 1998. After 8-year development, world’s first plant-based vaccine against Newcastle disease virus (NDV) was approved by the United States Department of Agriculture (USDA) for poultry.

Mechanism for production of plant-based oral vaccines against animal diseases

Fig1. Mechanism for production of plant-based oral vaccines against animal diseases. (Shahid and Daniell, 2016)

The advantages of Plant-based Vaccines

Compared to conventional vaccine methods, plant-based vaccines are endowed with following strengths:

  • Economically effective for they are free of cold-chain transport
  • No need to worry about being contaminated by toxins and pathogens, which usually occurs in bacterial vaccines production
  • Impossibility of reverse virulence
  • Easy to expand production scale
  • Easy for storage

Our Plant-based Vaccines platform

As a promising technology to produce vaccines, plant-based vaccines development is restricted with respect to the option of suitable antigen, the efficient expression system for plant host and the issues of consistency of dosage. Creative Biolabs now provides a range of optimization strategy services for our customers.

  • Various plant bioreactors
  • Mature chloroplast transformation technologies
  • Professional strategies to enhance gene delivery efficiency
  • Strategies for antigen selection and expression
  • Dosage consistency design

Creative Biolabs leads a professional team and specializes in plant-based vaccines with over-10 -year experiences, we are of fully confidence to remove all the barriers in the way developing a safe, cost-effective and protective vaccine using plant for you. Leave the difficulties to us and bring the exciting results home.

Reference

  1. N. Shahid and H. Daniell, Plant-based oral vaccines against zoonotic and non-zoonotic diseases. Plant Biotechnol J 14, 2079-2099 (2016).

Our services are for research use only. We do not provide services directly to individuals.

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