SuperStable™ Thermostability Technology for Stable Storage of Vaccines

The storage and transportation of vaccines is an important issue in the effectiveness of vaccines. Currently, attenuated viral vaccines are still an important class of vaccines that are often temperature-sensitive and require additional equipment for storage and transportation, which limits the use of vaccines in some developing countries. It also increases the cost of vaccination. As a pioneer in the vaccine industry, Creative Biolabs has conducted extensive research on this issue and developed a technology that makes it a reality to store vaccines at room temperature.

Background

Temperature is a major factor affecting the efficacy of vaccines, so they must be stored in strict accordance with the storage temperature requirements of various vaccines. Most attenuated freeze-dried vaccines (including allogeneic vaccines) should be stored frozen below -15°C for up to 2 years, while oil emulsion inactivated vaccines should not be frozen and preserved. Freezing will lead to stratification and invalidation of vaccines. They should usually be stored in an environment of 2°C ~ 8°C, valid for 1 year. If the temperature does not meet the requirements, the validity period will be shortened. The production, distribution, and storage of such heat-fragile vaccines often require additional cold chains, but cold chains are often expensive and at risk of losing vaccines. For some countries where facilities are scarce, vaccines are necessary, but equipment such as cold chains is difficult to achieve. So how to keep the vaccine at room temperature and still maintain efficacy is a very important issue.

SuperStable™ - Thermostability Technology for Stable Storage of Vaccines

Vaccines - Creative Biolabs

SuperStable™ is a technology designed to preserve heat-sensitive viruses, vaccines, and proteins. Those bio-drugs fragile at high temperatures can be successfully stored at room temperature and maintain their original efficacy after applying this technology. SuperStable™ is formulated with simple sugars and non-toxic small molecules (FDA-approved, also found in natural diets, pharmaceuticals and health supplements), mixed with vaccines at discrete concentrations and ratios during the filling process of the vaccine. SuperStable™ replaces their electrostatic interactions by replacing the hydration shell of water. After the water is removed, the viral capsid remains able to maintain the correct conformation and infectivity.

Highlight Features of SuperStable™

  • A broad range of storage temperature from 4°C to 37°C for up to 2-3 years
  • Applicable to liquid or lyophilized dosage forms
  • Suitable for a wide range of biological products, such as viruses, vaccines, biological materials, etc.
  • Safe and simple
  • Friendly to vaccines containing alum
  • Scalable
  • The stable and independent effect

Creative Biolabs' superior SuperStable™ technology makes vaccine storage easier while ensuring the efficacy of the vaccine at the same time. SuperStable™ is friendly not only for vaccines but also for other thermally liable biological products, safe, simple and scalable. If you are interested in this technology, please don't hesitate to contact us.


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