Vaccine for Furry Animals Allergy

Allergy to cats, dogs, or other furry animals is common in society and the prevalence of sensitization to pets has increased. Although the best treatment is avoidance, it is often difficult to achieve as well as not being well accepted by the patients. Therefore, new methods are urgently needed. Vaccines can provide disease-specific causative treatment by inducing tolerance to allergens and preventing the progression of allergic diseases, and play an increasingly important role in the prevention and control of allergic diseases.

Background of Furry Animals Allergy

Vaccines for Furry Animals Allergy– Creative Biolabs

Allergy to furry animals, cats, and dogs, in particular, has been recognized for many years and is considered to be a major risk factor for the development of asthma and rhinitis. The most common furry animals include dogs and cats, followed by rabbit, guinea pig, horse, and exotic animals. Identification and characterization of allergic components are critical to improving the diagnosis and treatment of patients with allergies to furry animals. Allergens from furry animals belong to a large number of protein families, most of which are lipocalins or albumins, some of which are secretoglobins or latherins. Most allergens from furry animals are found in dust and on airborne particles in homes, but also in public facilities such as schools or daycare centers.

Table 1. Defined furry animal allergens

Animal
Major allergen
Other allergens
Cat
Fel d 1 (uteroglobin)
Fel d 2 (albumin)
Fel d 4 (lipocalin)
Fel d 7 (VEGP)
Fel d 3 (cystatin)
Fel d 5w (cat IgA)
Fel d 8 (latherin-like)
Dog
Can f 1 (lipocalin)
Can f 2 (lipocalin)
Can f 4 (lipocalin)
Can f 6 (lipocalin)
Can f 3 (albumin)
Can f 5 (arginine esterase)
Guinea pig
Cav p 1 (lipocalin)
Cav p 2 (lipocalin)
Cav p 3 (lipocalin)
Cav p 4 (albumin)
Horse
Equ c 1 (lipocalin)
Equ c 2 (lipocalin)
Equ c 4 (latherin)
Equ c 3 (albumin)
Rabbit
Ory c 1 (lipocalin)
Ory c 3 (lipocalin)

DNA Vaccines

Injection of DNA vaccines encoding allergen genes from furry animals results in the synthesis of the antigen by host cells and most likely presentation by, and opens up an entirely new approach to vaccine development. DNA vaccines encoding allergen genes have two effects on allergic diseases. First, most of the allergens produced by transfected cells are intracellular, and only a very small number of allergens are secreted. Therefore, it is unlikely that allergen gene vaccination will induce anaphylactic reactions. Second, mouse immunization with DNA-encoding protein antigens mostly induces a Th1 immune response, while immunization with the protein mostly generated a Th2 response. This applies not only to protein antigens but also to human allergens.

T Cell Epitope Peptides Vaccines

As an alternative to hypoallergens, T cell peptides vaccines containing major allergen epitopes from allergy have been generated from the primary structures of Fel d 1, Can f 1, and Equ c 1. These peptides show no or markedly reduced ability to cross-link IgE epitopes, are unable to cross-link IgE on basophils and mast cells, and thus do not induce acute allergic adverse events. Their mechanism of action is through induction of T cell tolerance, which may improve immune responses to allergens primarily by inducing regulatory T cells and inducing linked epitope inhibition.

Our Services for Vaccine of Furry Animals Allergy

Creative Biolabs has a variety of mature and comprehensive platforms and technologies for vaccine development, and we are committed to providing the best solutions and customized protocols for vaccine design and development for animal allergy. We offer the following related services:

  • Identification of allergens epitope from furry animals
  • Cloning, expression, purification, and sequencing of recombinant major allergens
  • Evaluation and data analysis of the immune effects of candidate vaccine
  • Provide specialized vaccine development designs and solutions based on customer needs

Creative Biolabs is a world leader in the field of vaccine development and has been dedicated to vaccine design services for many years. We have experienced experts and advanced platforms that are able to provide excellent vaccine design and development services for allergic disease. If you are interested in our services, please contact us for more details.


Our services are for research use only. We do not provide services directly to individuals.


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