Human Noggin Protein (Gln 28-Cys 232) [Fc] (VAng-2617Lsx)
Human Noggin protein, human IgG1 Fc tag, was expressed in human 293 cells. (Uniprot ID: NP_005441)
Datasheet
Specifications
Source
HEK293 cells
Target
Noggin
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
50 mM Tris, 100 mM Glycine, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
NOG (Noggin) binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Diseases associated with NOG include Tarsal-Carpal Coalition Syndrome and Brachydactyly, Type B2.
Alternative Names
Noggin, NOG, SYM1, SYNS1
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