Recombinant Flt-3 Protein (Asn 27-Ser 543) [Fc] (VAng-1575Lsx)
Human Flt-3, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: P36888-1)
Datasheet
Specifications
Source
HEK293 Cells.
Target
Flt-3
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Tris with Glycine, Arginine and NaCl, pH 7.5.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
FLT3 (Fms Related Tyrosine Kinase 3) is a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Alternative Names
Flt-3, Flk-2, STK-1, CD135, FLK2, FLT-3
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