Recombinant Mouse AMH Protein (aa 21-555) [His] (VAng-3010Lsx)
Recombinant Mouse AMH protein was expressed in E. coli. (Uniprot ID: Q8K592)
Applications
SDS-PAGE; WB; ELISA.
Formulation
20 mM Tris, 150 mM NaCl, pH 8.0, Containing 1 mM EDTA, 1 mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Purity
> 97% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Introduction
AMH (Anti-Mullerian Hormone) a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.
Alternative Names
MIS, AMH, MIF
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