MMP-2

MMP-2 is involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Activation of MMP-2 requires proteolytic processing. A complex of membrane type 1 MMP (MT1-MMP/MMP14) and tissue inhibitor of metalloproteinase 2 recruits pro-MMP 2 from the extracellular milieu to the cell surface. Activation then requires an active molecule of MT1-MMP and auto catalytic cleavage. Clustering of integrin chains promotes activation of MMP-2. Another factor that will support the activation of MMP-2 is cell-cell clustering. A wild-type activated leukocyte cell adhesion molecule (ALCAM) is also required to activate MMP-2.

CAT	Product Name	Source	Product Overview	Target	Type	Size	Price
VAng-Cr4017	Recombinant Human MMP-2 Protein (aa 1-660)	Human	Recombinant Human MMP-2 Protein (Met 1-Cys660) was expressed in HEK293 Cells, with a molecular weight of 72 kDa. (Accession ID: NP_004521.1)	MMP-2	Tumor Antigens	20 µg	Inquiry
VAng-Cr4018	Recombinant Mouse MMP-2 Protein (aa 409-622) [His]	Mouse	Recombinant Mouse MMP-2 Protein (Met409-Cys622) fused with a His tag at N-terminus was expressed in HEK293 Cells, with a molecular weight of 30.9 kDa. (Accession ID: NP_032636.1)	MMP-2	Tumor Antigens	5 µg	Inquiry
VAng-2570Lsx	Human MMP-2 Protein (Ala 30-Cys 660) [His]	HEK293 cells	Human MMP-2 protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAH02576)	MMP-2	Tumor Antigens	50 µg	Inquiry
VAng-2571Lsx	Human MMP-9 Protein (Ala 20-Pro 469) [His]	HEK293 cells	Human MMP-9 protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAH06093)	MMP-2	Tumor Antigens	50 µg	Inquiry

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