Recombinant Human MMP-2 Protein (aa 1-660) (VAng-Cr4017)

Recombinant Human MMP-2 Protein (Met 1-Cys660) was expressed in HEK293 Cells, with a molecular weight of 72 kDa. (Accession ID: NP_004521.1)

Datasheet

Specifications

Source

Human

Target

MMP-2

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

MMP-2 is involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Activation of MMP-2 requires proteolytic processing. A complex of membrane type 1 MMP (MT1-MMP/MMP14) and tissue inhibitor of metalloproteinase 2 recruits pro-MMP 2 from the extracellular milieu to the cell surface. Activation then requires an active molecule of MT1-MMP and auto catalytic cleavage. Clustering of integrin chains promotes activation of MMP-2. Another factor that will support the activation of MMP-2 is cell-cell clustering. A wild-type activated leukocyte cell adhesion molecule (ALCAM) is also required to activate MMP-2.

Alternative Names

MMP2; CLG4; CLG4A; MMP-II; MONA; TBE-1; matrix metallopeptidase 2