MPL
MPL is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin, CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.| CAT | Product Name | Source | Product Overview | Target | Type | Datasheet | Size | Price |
|---|---|---|---|---|---|---|---|---|
| VAng-Cr3767 | Recombinant MPL Protein (Met1-Trp491) [His] | Mammalian cells | Recombinant MPL Protein (Met1-Trp491) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 66-76 kDa. (Uniprot ID: P40238) | MPL | Tumor Antigens |  |
100 µg | Inquiry |
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