MHC-binding Peptidome Identification Service

Creative Biolabs proudly introduces our professional MHC-binding peptidome identification service to our clients all over the world. Based on our advanced technology platform and extensive experience, now we have developed a method to capture all MHC molecules and harvest the corresponding peptides efficiently. After a series of analysis and database research, we can finally offer the complete profile of the MHC-binding peptidome.

Major histocompatibility complex (MHC) molecules is a set of cell surface proteins which are essential for the acquired immune system. The main function of MHC is to bind a pathogen-derived peptide chain and show the pathogen on the cell surface for recognition by the T-cell receptor (TCR) of T cells. In this case, identification of MHC-binding peptides is a prerequisite in the rational design of T-cell based peptide vaccines. However, only certain peptides can bind to any given MHC molecule. The identification of MHC-binding peptides will promote the development of vaccines and immunotherapeutics for autoimmune disease and cancer.

MHC-binding Peptidome Identification ServiceFig. 1 The structure of the MHC-binding peptide.

MHC-binding peptidomics is one of the most proven services in Creative Biolabs. Our scientists have been working in this field for many years, and the key technical advantage is that we have optimized a series of enrichment methods for antigen presenting protein complexes on cell surfaces as well as a highly efficient peptide elution and capture method, through which we could highly specifically enrich the antigen peptides presented on the cell surface, including neoantigens.

There are general 5 steps for the service of MHC-binding peptidome identification:

  1. The enrichment of MHC molecules and the harvest of MHC complexes
  2. Sample preparation and digestion
  3. SCX cleaning and 2D fractionation
  4. Liquid chromatography assay
  5. Protein database searching and data analyze

For our clients’ different requirement, we can design and perform the specific protocols. If your goal is to completely understand the peptides presented on the surface of the cell, we can perform a qualitative assay and provide the deep profiling dataset. And if your target is to detect a specific antigen, we will accomplish a quantitative assay and give you an accurate result.

Creative Biolabs has the capability to enable you to free up your time for core work and project. What’s more, we can give the reasonable prices, rapid turnaround, and prompt customer services for our customs. If you are interested in our MHC-binding peptidome Identification service, please do not hesitate to inquire us and send us your detailed request.

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