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NativeExtract™ Recombinant Full Length Human CLCN1 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW116)

This product is recombinant Human CLCN1 protein in native nanodisc form. The synthetic compound we developed can solubilize the CLCN1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLCN1
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 108.6 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CLCN1
  • Full Name
  • Chloride Voltage-Gated Channel 1
  • Introduction
  • The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • Chloride Voltage-Gated Channel 1; Chloride Channel Protein, Skeletal Muscle; Chloride Channel, Voltage-Sensitive 1; Chloride Channel 1, Skeletal Muscle; ClC-1; CLC1; Thomsen Disease, Autosomal Dominant; Chloride Channel Protein 1

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