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NativeExtract™ Recombinant Full Length Human CLCN4 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW113)

This product is recombinant Human CLCN4 protein in native nanodisc form. The synthetic compound we developed can solubilize the CLCN4 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CLCN4
  • Protein Length
  • Full length
  • Protein Class
  • Ion Channel
  • Molecular Weight
  • 84.9 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CLCN4
  • Full Name
  • Chloride Voltage-Gated Channel 4
  • Introduction
  • The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.
  • Alternative Names
  • Chloride Voltage-Gated Channel 4; Chloride Channel, Voltage-Sensitive 4; Chloride Channel Protein 4; Chloride Transporter ClC-4; Chloride Channel 4; ClC-4

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