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NativeExtract™ Recombinant Full Length Human FXYD5 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW275)

Datasheet
This product is recombinant Human FXYD5 protein in native nanodisc form. The synthetic compound we developed can solubilize the FXYD5 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • FXYD5
  • Protein Length
  • Full length
  • Protein Class
  • Transporter
  • Molecular Weight
  • 19.5 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • FXYD5
  • Full Name
  • FXYD Domain Containing Ion Transport Regulator 5
  • Introduction
  • This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • FXYD Domain Containing Ion Transport Regulator 5; Dysadherin; FXYD Domain-Containing Ion Transport Regulator 5; DYSAD; IWU1; Keratinocytes Associated Transmembrane Protein 1

Case Studies

Customer reviews and Q&As    

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