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NativeExtract™ Recombinant Full Length Mouse CLDN18.1 Protein (Nanodisc, FLAG- & Strep-tagged) (CAT#: SYF-0426-CW286)

This product is recombinant Mouse CLDN18.1 protein in native nanodisc form. The synthetic compound we developed can solubilize the CLDN18.1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Mouse
  • Target Protein
  • CLDN18.1
  • Protein Length
  • Full length
  • Protein Class
  • CD
  • Molecular Weight
  • 28.1 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • The recombinant protein is constructed with FLAG Tag & Strep Tag at C-terminus.
  • Protein Format
  • Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CLDN18.1
  • Full Name
  • Claudin 18
  • Introduction
  • This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is a downstream target gene regulated by the T/EBP/NKX2.1 homeodomain transcription factor. Four alternatively spliced transcript variants resulted from alternative promoters and alternative splicing have been identified, which encode two lung-specific isoforms and two stomach-specific isoforms respectively. This gene is also expressed in colons, inner ear and skin, and its expression is increased in both experimental colitis and ulcerative colitis.

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