Human Semaphorin 4A Protein (Gly 33-His 683) [His] (VAng-2688Lsx)
Human Semaphorin 4A (SEMA4A) protein, His tag, was expressed in human 293 cells. (Uniprot ID: AAH20974)
Datasheet
Specifications
Source
HEK293 cells
Target
SEMA4A
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
SEMA4A (Semaphorin 4A) is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10).
Alternative Names
SEMA4A, SEMAB, SEMB, Semaphorin-4A, Semaphorin-B
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