Oral Delivery System Bioencapsulated in Plant Cells

Plant cells can serve as a natural vehicle for oral administration because of their properties of resistant to degradation when passing through the digestive tract. Creative Biolabs is a leading company in vaccine delivery industry. Based on years of experience and a team of professional scientists, we have successfully established a top oral delivery platform based on plant cells and provide specialized support for your research. We can accommodate the specific attributes of your project and provide flexible and integrated solutions.

Why Use Plant Cells?

The manufacturing systems mainly used for protein drugs, such as bacteria, yeast and mammalian cells, have many disadvantages, such as, 1) These expressed proteins must be extracted and purified, which requires complicated and expensive processes as well as refrigeration and transportation; 2) These expressed proteins have short shelf life and there is a risk of contamination by toxins or human pathogens; 3) Patient compliance is low because the injection usually requires the administration of a medical professional; 4) Expensive and limited production capacity; 5) Most of these expressed proteins cannot be delivered orally because the presence of proteases in the stomach acid and digestive system causes them to degrade before passing through the intestinal barrier.

Plants offer an ideal alternative to traditional manufacturing systems. Plants are not the host of human pathogens. The large amount of lignin and cellulose contained in the plant cell wall provides natural protection for protein drugs because human enzymes cannot destroy the glycosidic bonds of plant cell wall carbohydrates. However, gut bacteria can digest plant cell walls and release bioencapsulated PD into the intestinal lumen.

Engineering plant cells to express protein drugs and lyophilization for oral delivery.

Fig.1 Engineering plant cells to express protein drugs and lyophilization for oral delivery. (Kwon KC. 2015)

Oral Delivery System Bioencapsulated in Plant Cells

The unique cellulosic wall of plant cells makes them resistant to degradation as they pass through the digestive tract, thus oral delivery of protein drugs can be carried out by the plant cells. Plant cells can be used as a natural carrier for oral administration and are now approved by FDA for the cost-effective production of protein drugs in GMP-grade large scale manufacturing.

Features of Our Services

  • Low cost.
  • More convenient than intravenous infusions and intramuscular and subcutaneous injections.
  • Better patient compliance and increased quality of life.
  • Strong stability and long shelf life. Protein drugs made in chloroplasts are very stable in lyophilized plant cells when stored at ambient temperature.
  • The freeze-drying process increases the concentration of protein drugs and eliminates bacterial contamination.

If you are interested in our services, please contact us to get more information or directly send us an online inquiry.

Reference

  1. Kwon KC and Daniell H. Low-cost oral delivery of protein drugs bioencapsulated in plant cells. Plant Biotechnol J. 2015, 13(8):1017-22.

All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.


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All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

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