Human EGFR Protein (Leu 25-Ser 645) [His] (VAng-1482Lsx)
Human EGFR, His tag, is expressed in HEK 293 cells. (Uniprot ID: P00533-1)
Datasheet
Specifications
Source
HEK293 Cells.
Target
EGFR
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
PBS, pH 7.4.
Purity
> 95% pure by SDS-PAGE.
Storage
Store at -20°C to -80°C.
Antigen Information
Introduction
EGFR is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. Deficient signaling of the EGFR and other receptor tyrosine kinases in humans is associated with diseases such as Alzheimer's, while over-expression is associated with the development of a wide variety of tumors. Interruption of EGFR signalling, either by blocking EGFR binding sites on the extracellular domain of the receptor or by inhibiting intracellular tyrosine kinase activity, can prevent the growth of EGFR-expressing tumours and improve the patient's condition.
Alternative Names
EGFR, ERBB, ERBB1, HER1, PIG61, mENA
Related Product
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