Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adrenoceptor beta 3 |
| Gene Name | ADRB3 |
| Uniprot | P13945 (Human); P25962 (Mouse) |
| Synonym | BETA3AR; adrenergic, beta-3-, receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor |
| Background | ADRB3 is a beta-adrenergic receptor, which belongs to the G protein-coupled receptor (GPCR) superfamily characterized by seven transmembrane domains of 22-28 amino acids. Structurally, the N-terminus of ADRB3 protein is extracellular and glycosylated. The C-terminus is intracellular and has no sites for phosphorylation by protein kinase A (PKA) and β-adrenoceptor kinase (βARK). TM3, TM4, TM5, and TM6 are essential for ligand binding. TM2 and TM7 are involved in Gs activation. The activation of this receptor produces several signaling pathways, including activation of adenylyl cyclase and cAMP-dependent phosphorylation. ADRB3 is insensitive to the commonly used beta-adrenergic receptor antagonists. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX323 | NativeExtract™ Human ADRB3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3542K | MemDX™ Membrane Protein Human ADRB3 (Adrenoceptor beta 3) Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0024X | MemDX™ Membrane Protein Human ADRB3 (Adrenoceptor beta 3) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0023X | MemDX™ Membrane Protein Human ADRB3 (Adrenoceptor beta 3) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
K**l: Seamless integration with SPR and crystallography workflows accelerated our functional studies.
17/May/2023
A***a: Custom thermostable ADRB3 mutants delivered in 3 weeks with detailed stability data.
24/Feb/2024
ADRB3 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
ADRB3 Variant Correction
Creative Biolabs offers ADRB3 variant correction services. ADRB3 gene therapy leverages precision genome-editing tools to address nonsynonymous polymorphisms such as the Trp64Arg variant, which disrupts receptor signaling kinetics and predisposes to obesity-related pathologies. Gene editing systems, coupled with homology-directed repair (HDR) templates, enable site-specific correction of this variant in adipocyte progenitor cells. Recent studies in murine models demonstrate restored ADRB3-mediated lipolysis and improved insulin sensitivity following ex vivo gene editing and autologous transplantation. Creative Biolabs provides optimized RNA design and validation services to enhance editing specificity for clinical translation.
AAV-Driven ADRB3 Overexpression in Thermogenic Fat Depots
Creative Biolabs offers AAV-driven ADRB3 overexpression services. Recombinant adeno-associated virus (AAV) serotypes engineered for adipose tissue tropism enable sustained ADRB3 overexpression in brown and beige adipocytes. Preclinical data reveal that intra-adipose injection of AAV9-ADRB3 constructs in diet-induced obese rodents elevates uncoupling protein 1 (UCP1) expression by 2.7-fold, augmenting energy expenditure and reducing adiposity. Creative Biolabs' proprietary AAV capsid optimization platform enhances transduction efficiency in thermogenically active depots while minimizing hepatic off-target effects.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADRB3 cell therapy. Please for more services.
Engineered T Cells with β3-Adrenergic Receptor Chimeric Antigen Receptors (CARs)
Creative Biolabs offers engineered T cells with β3-adrenergic receptor CARs services. CAR-T cells expressing ADRB3-targeting extracellular domains are being explored to selectively deplete hypertrophic adipocytes in visceral fat. These cells secrete matrix metalloproteinases upon receptor engagement, inducing localized lipolysis without systemic β3-agonist exposure. In vitro co-culture models confirm a 68% reduction in mature adipocyte viability within 72 hours. Creative Biolabs offers end-to-end CAR construct synthesis, including extracellular domain humanization and safety switch integration.
Mesenchymal Stem Cells (MSCs) Secreting ADRB3 Agonist Peptides
Creative Biolabs offers MSCs secreting ADRB3 agonist peptides development services. MSCs bioengineered to secrete peptide analogs of ADRB3 agonists achieve sustained receptor activation in adipose niches. Encapsulation within thermoresponsive hydrogels allows localized implantation, with preclinical data showing a 41% increase in subcutaneous fat UCP1 density over 4 weeks. Creative Biolabs' MSC differentiation protocols enhance secretory capacity while maintaining multipotency for scalable manufacturing.
Adipocyte Progenitor Reprogramming via Small-Molecule-Induced ADRB3 Transactivation
Creative Biolabs offers adipocyte progenitor reprogramming services. Small-molecule libraries targeting ADRB3-linked epigenetic regulators are screened to reprogram adipocyte progenitors toward thermogenic lineages. Hit compounds inducing PPARγ coactivator-1α (PGC-1α) expression demonstrate 3.1-fold higher mitochondrial biogenesis in differentiated beige adipocytes. Creative Biolabs' high-content screening platforms integrate RNA sequencing to map lineage commitment trajectories.
While these modalities illustrate ADRB3's therapeutic versatility, protocol standardization across in vitro, ex vivo, and in vivo systems remains a translational bottleneck. Creative Biolabs' cross-platform expertise in gene-editing validation, AAV vector optimization, and stem cell engineering directly addresses these challenges. Our team provides end-to-end support from target validation to IND-enabling studies, ensuring seamless integration of ADRB3-focused mechanisms into your development pipeline.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
