Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Glutamate metabotropic receptor 5 |
| Gene Name | GRM5 |
| Uniprot | P41594 (Human); Q3UVX5 (Mouse) |
| Synonym | mGlu5; GPRC1E; MGLUR5; PPP1R86; glutamate receptor, metabotropic 5; protein phosphatase 1, regulatory subunit 86 |
| Background | mGluRs are family C G-protein-coupled receptors that are featured structurally by the presence of a large extracellular domain. Based on sequence homology, G-protein coupling, and ligand selectivity, mGluRs are subclassified into three groups: group I, group II, and group III. mGluR5, also known as GRM5, together with mGluR1, are group I mGluRs that are associated with Gq proteins and are coupled to phospholipase C. mGluR5 exists as two main splice variants: mGluR5a and mGluR5b. This receptor is localized postsynaptically and is highly expressed in the central nervous system, including the hippocampus, corpus striatum, cerebral cortex, and in basal ganglia. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX188 | NativeExtract™ Human GRM5 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX0044K | MemDX™ Membrane Protein Human GRM5 for Antibody Discovery, Partial (19-509aa) | Partial | N/A | |
| Please contact us for more products or customization | ||||
I***c: Highly pure GRM5 protein with exceptional binding activity.
15/May/2023
J***b: Tailored GRM5 construct with optimized solubility and stability.
06/Dec/2023
We provide tailored solutions to meet your specific requirements. Please inquire us for more services.
Creative Biolabs offers allele correction services. Disruptive mutations in GRM5, encoding the metabotropic glutamate receptor 5, are increasingly implicated in neuropsychiatric and cognitive disorders. Allele-specific editing offers a transformative strategy to silence hyperactive GRM5 variants while preserving wild-type receptor function. For example, dual-guide RNA systems enable selective targeting of pathogenic alleles harboring single-nucleotide polymorphisms within regulatory domains. Preclinical models demonstrate that allele-specific excision normalizes aberrant glutamate signaling cascades, ameliorating synaptic plasticity deficits. Creative Biolabs' proprietary RNA design platform optimizes specificity for such nuanced targeting, ensuring minimal off-template edits—a critical consideration for clinical translation.
Creative Biolabs offers AAV-delivered dominant-negative GRM5 constructs services. Adeno-associated virus (AAV) vectors engineered with truncated GRM5 extracellular domains act as competitive inhibitors of endogenous receptor oligomerization. This approach exploits the receptor's obligate dimerization mechanism, effectively suppressing glutamate-induced intracellular calcium flux. In rodent models of Fragile X syndrome, intrahippocampal delivery of these constructs reduced repetitive behaviors and rescued dendritic spine abnormalities. Creative Biolabs' expertise in AAV capsid optimization ensures efficient blood-brain barrier penetration, a pivotal factor for central nervous system (CNS)-focused therapies.
Creative Biolabs offers dual-promoter shRNA development services. Tissue-specific knockdown of GRM5 via short hairpin RNA (shRNA) systems allows precise modulation of receptor expression in pathological niches. For instance, coupling neuron-specific promoters (e.g., SYN1) with inducible tetracycline-responsive elements enables reversible suppression of GRM5 in epilepsy-associated hyperexcitable circuits. Creative Biolabs' validated shRNA libraries and RNA-seq validation pipelines guarantee target engagement without compromising adjacent glutamatergic signaling components.
Creative Biolabs offers comprehensive and innovative services to drive the development of GRM5 cell therapy. Please inquire with us for more services.
Creative Biolabs offers CAR-T constructs services. Chimeric antigen receptor (CAR)-T cells engineered to recognize GRM5's extracellular epitopes show promise in malignancies where receptor overexpression drives oncogenic signaling. In glioblastoma models, GRM5-directed CAR-T cells selectively lysed tumor-infiltrating stem cells while sparing healthy glutamatergic neurons. Creative Biolabs' hybridoma development services generate high-affinity anti-GRM5 scFv domains, critical for minimizing on-target, off-tumor toxicity—consult our team to tailor epitope specificity for your tumor antigen profile.
Creative Biolabs offers iPSC-derived GRM5+ neurons development services. Differentiating iPSCs into GRM5-expressing glutamatergic neurons offers a path to reconstruct dysregulated circuits in neurodevelopmental disorders. Layer-specific cortical neurons generated via Creative Biolabs' protocols restore synaptic connectivity in vitro, as validated by multielectrode array (MEA) assays. Our end-to-end differentiation protocols, including small-molecule modulation of WNT and BMP pathways, ensure >90% purity of target neuronal populations.
Creative Biolabs offers macrophage reprogramming services. GRM5's role in modulating neuroinflammation is exploited by engineering macrophages with lentiviral constructs linking receptor activation to anti-inflammatory cytokine secretion (e.g., IL-10). In Alzheimer's models, these “smart” macrophages selectively dampen amyloid-β-induced neurotoxicity while preserving phagocytic clearance. Creative Biolabs' lentiviral tropism engineering enhances myeloid-specific transduction, a prerequisite for clinical efficacy.
The complexities of GRM5 modulation demand partners with deep mechanistic insight and technical agility. Creative Biolabs' cross-disciplinary teams offer tailored solutions—from AAV tropism optimization to CAR-T functional validation—ensuring your therapeutic candidate achieves preclinical milestones with confidence. Contact us to schedule a consultation and leverage our cutting-edge platforms for your GRM5-focused gene or cell therapy program.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
