Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Glutamate metabotropic receptor 7 |
| Gene Name | GRM7 |
| Uniprot | Q14831 (Human); Q68ED2 (Mouse) |
| Synonym | GLUR7; MGLU7; GPRC1G; MGLUR7; NEDSHBA; PPP1R87; glutamate receptor, metabotropic 7; protein phosphatase 1, regulatory subunit 87 |
| Background | GRM7 (mGluR7) is one of the group III metabotropic glutamate receptors (mGluRs) that are coupled predominantly to Gi/o proteins. They are family C G-protein coupled receptors that are generally characterized by the presence of a large extracellular domain that contains the endogenous ligand-binding site. Different splice variants of GRM7 exist due to alternative splicing. This receptor exhibits a wide distribution throughout the entire brain and is highly localized to the active zones of synapses. Moreover, they have displayed an extremely low affinity for glutamate and only become active when glutamate levels are very high. It modulates excitatory neurotransmission and synaptic plasticity by inhibiting neurotransmitter release. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX376 | NativeExtract™ Human GRM7 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MP0498X | MemDX™ Membrane Protein Human GRM7 (Glutamate metabotropic receptor 7) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MPX0045K | MemDX™ Membrane Protein Human GRM7 Expressed in CHO for Antibody Discovery, Partial (35-521aa) | CHO cells | Partial | N/A |
| Please for more products or customization | ||||
L***s: Consistent lot-to-lot performance.
19/Feb/2023
N***an: Tailored GRM7 extracellular domain exhibited precise glycosylation and ligand-binding affinity.
17/Aug/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers AAV-mediated GRM7 expression regulation services. Adeno-associated virus (AAV) vectors enable cell-specific delivery of therapeutic constructs to modulate GRM7 expression in neuronal populations. Preclinical studies demonstrate that AAV-driven GRM7 overexpression or knockdown in cortical neurons can restore neurodevelopmental pathways disrupted in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) models. Such approaches refine synaptic glutamate signaling, offering a targeted strategy to address neurodevelopmental imbalances. Creative Biolabs' expertise in optimizing AAV tropism for CNS applications ensures maximal transduction efficiency and therapeutic specificity.
Creative Biolabs offers gene editing services. Gene editing allows precise correction of GRM7 regulatory variants linked to CREB phosphorylation dysregulation. By restoring physiological GRM7 activity, this method mitigates aberrant neuroprogenitor proliferation and promotes neuronal maturation—critical for disorders with cortical malformations. Creative Biolabs' validated RNA libraries and in vivo delivery platforms accelerate the development of GRM7-editing therapies.
Creative Biolabs offers pharmacogenetic modulation services. Targeting GRM7-coupled pathways offers an indirect yet potent therapeutic avenue. Viral vector-mediated expression of CREB modulators in GRM7-expressing cells can stabilize transcriptional outputs, enhancing neuronal differentiation in ASD models. For partnerships in pathway analysis and vector design, Creative Biolabs provides end-to-end solutions to advance these strategies.
Creative Biolabs offers comprehensive and innovative services to drive the development of GRM7 cell therapy. Please for more services.
Creative Biolabs offers GRM7-engineered neural stem cell transplantation development services. Transplanting GRM7-modified neural stem cells into dysregulated cortical regions can replenish depleted neuronal populations. These cells, pre-differentiated to express GRM7 dynamically, integrate into host circuits and restore glutamate-mediated inhibitory signaling. Creative Biolabs' stem cell culture systems and lineage-tracking assays ensure reproducible differentiation and functional validation.
Creative Biolabs offers microglial reprogramming services. Repurposing microglia to overexpress GRM7 enhances their capacity to resolve neuroinflammatory cascades in neurodegenerative models. This approach leverages endogenous immune cells to modulate synaptic pruning and glutamate homeostasis—key for diseases like Parkinson's or Alzheimer's. Creative Biolabs' lentiviral transduction kits enable efficient microglial engineering with minimal off-target effects.
Creative Biolabs offers CAR-T cells targeting GRM7 signaling hubs development services. CAR-T cells engineered to recognize GRM7-associated surface markers selectively eliminate hyperactive neuronal subsets in epilepsy or neuropathic pain models. This immunotherapeutic strategy combines specificity with scalability, supported by Creative Biolabs' CAR construct optimization services.
GRM7's role in neurodevelopmental and psychiatric disorders demands innovation at the gene and cellular levels. Creative Biolabs offers tailored solutions—from AAV vector design to stem cell engineering—to accelerate your therapeutic pipeline. to leverage cutting-edge tools for GRM7 target validation, preclinical testing, and regulatory-grade manufacturing.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
