Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Prostaglandin D2 receptor 2 |
| Gene Name | PTGDR2 |
| Uniprot | Q9Y5Y4 (Human); Q9Z2J6 (Mouse) |
| Synonym | DP2; DL1R; CD294; CRTH2; GPR44; G-protein coupled receptor 44; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; chemoattractant receptor-homologous molecule expressed on TH2 cells; putative G-protein coupled receptor 44 |
| Background | PTGDR2 is a human protein encoded by the PTGDR2 gene. It has also been designated as CD294 (cluster of differentiation 294). It is a member of the class of prostaglandin receptors which bind with and respond to various prostaglandins. PTGDR2 along with Prostaglandin DP1 receptor are receptors for prostaglandin D2 (PGD2). Activation of PTGDR2 by PGD2 or other cognate receptor ligands has been associated with certain physiological and pathological responses, particularly those associated with allergy and inflammation, in animal models and certain human diseases. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX371 | NativeExtract™ Human PTGDR2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3526K | MemDX™ Membrane Protein Human PTGDR2 (Prostaglandin D2 receptor 2) Expressed in vitro E.coli expression system, Full Length | E.colicell-free | Full length | Detergent |
| Please for more products or customization | ||||
T**e: I recently ordered PTGDR2 Protein from Creative Biolabs, and I couldn't be more satisfied! The product arrived on time and was packaged perfectly. The quality of the protein is outstanding, and it has been working exactly as expected in my experiments.
24/ Apr/2023
L***c: They kept me updated on the status of my order and were quick to address any questions I had. I'm very impressed with their product and service. If you need high-quality proteins, Creative Biolabs is the place to go!
10/ Dec/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers targeting the PGD2/PTGDR2 signaling pathway research services. The PGD2/PTGDR2 signaling cascade has been demonstrated to impact the self-renewal ability of cancer stem cells (CSCs) through the regulation of autophagy. PGD2 stimulates the expression of PTGDR2, which competes with ATG4B for binding to the E3 ligase RNF5. As a result, the degradation of ATG4B is diminished, and autophagy is triggered. This pathway can serve as a target for cancer treatment. By adjusting PGD2 concentrations or directly aiming at PTGDR2, autophagy can be enhanced, and the stem-like properties of CSCs can be suppressed.
Creative Biolabs offers gene knockdown and overexpression services. Small interfering RNA (siRNA) is applicable for reducing PTGDR2 expression within cancer cells. This method has been shown to impede the autophagy activation induced by PGD2 and decrease the self-renewal potential of gastric cancer stem cells. In contrast, employing viral vectors or plasmids to overexpress PTGDR2 can be utilized to augment the autophagy mechanism and possibly suppress tumor development.
Creative Biolabs offers biomarker identification services. PTGDR2 expression levels in peripheral blood have been identified as a potential biomarker for asthma and other inflammatory conditions. This suggests that similar approaches could be used to identify patients who may benefit from PTGDR2-targeted therapies. Whole-transcriptome RNA sequencing and qPCR validation studies can be used to identify and validate PTGDR2 expression levels in various diseases, providing a basis for personalized medicine.
Creative Biolabs offers comprehensive and innovative services to drive the development of PTGDR2 cell therapy. Please for more services.
Creative Biolabs offers cell isolation and expansion services. Use magnetic bead-based cell separation techniques to isolate PTGDR2-positive cells from peripheral blood or other sources. This method is efficient and allows for the enrichment of specific cell populations. Once isolated, expand PTGDR2-positive cells ex vivo using optimized culture conditions. This step is crucial for obtaining sufficient numbers of cells for therapeutic applications.
Creative Biolabs offers functional assay services to assess PTGDR2-modified cells. Since PTGDR2 is involved in autophagy regulation, assess the autophagic activity of modified cells using assays such as LC3-II conversion, p62 degradation, and transmission electron microscopy.
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
