Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Prostaglandin E receptor 3 |
| Gene Name | PTGER3 |
| Uniprot | P43115 (Human); P30557 (Mouse) |
| Synonym | EP3; EP3e; EP3-I; EP3-II; EP3-IV; EP3-VI; PGE2-R; EP3-III; lnc003875; prostaglandin E2 receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; prostaglandin E receptor 3 (subtype EP3); prostaglandin receptor (PGE-2); prostanoid EP3 receptor |
| Background | PTGER3, also known as EP3, is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER3. It is one of four identified EP receptors, the others being EP1, EP2, and EP4, all of which bind with and mediate cellular responses to PGE2. Besides, it has demonstrated that PTGER3 enables to couples to Gi to suppress PKA activity. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX68 | NativeExtract™ Human PTGER3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3521K | MemDX™ Membrane Protein Human PTGER3 (Prostaglandin E receptor 3) Expressed in vitro E.coli expression system, Full Length | E.colicell-free | Full length | Detergent |
| MP1057X | MemDX™ Membrane Protein Human PTGER3 (Prostaglandin E receptor 3) with N-GST tag for Antibody Discovery | Wheat germ cell -free | Full length | N/A |
| MP1056X | MemDX™ Membrane Protein Human PTGER3 (Prostaglandin E receptor 3) without tag for Antibody Discovery | Wheat germ cell -free | Full length | Liposome |
| Please for more products or customization | ||||
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27/ Apr/2024
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Creative Biolabs offers gene delivery services. Microorganisms like viruses frequently serve as carriers to transfer the therapeutic genes associated with PTGER3 into cells. Adenoviruses, AAVs, and lentiviruses are frequently employed for this purpose. These viral entities can be altered to transport the specific PTGER3-related genes needed. For instance, AAVs are favored due to their reduced immunogenic properties and ability to enable sustained gene expression over an extended period. They can be customized to target particular cell populations, guaranteeing that the gene therapy reaches exactly the cells where the PTGER3 gene plays a crucial role.
Creative Biolabs offers therapeutic gene design services. The emergence of pathogenic variants within the PTGER3 locus necessitates therapeutic interventions tailored to rectify allelic dysfunction. Depending on the mutational landscape, two principal modalities may be pursued: gene augmentation via delivery of a wild-type PTGER3 transgene or direct genomic correction employing programmable nucleases or base-editing platforms to repair defective alleles. For example, loss-of-function mutations arising from single-nucleotide substitutions could be addressed through homology-directed repair (HDR) mechanisms.
Creative Biolabs offers overexpression or underexpression regulation services. In disorders characterized by insufficient PTGER3 transcriptional activity, precise augmentation could be achieved through delivery of a therapeutic transgene cassette encoding the target gene, coupled with regulatory sequences to potentiate expression. The interplay between PTGER3 and its downstream effectors introduces complexity; thus, therapeutic constructs must account for feedback mechanisms that could paradoxically counteract intervention efficacy. It is plausible that transient modulation, rather than sustained alteration, might mitigate unintended compensatory pathways. Furthermore, the selection of delivery vectors—whether viral (e.g., AAV, lentivirus) or non-viral (e.g., lipid nanoparticles)—must align with tissue tropism and duration-of-effect requirements.
Creative Biolabs offers comprehensive and innovative services to drive the development of PTGER3 cell therapy. Please for more services.
Creative Biolabs offers protein analysis services. Western blotting and immunocytochemistry are commonly used to detect and quantify the PTGER3 protein. Western blotting separates proteins by size and then uses antibodies to detect the presence of PTGER3. Immunocytochemistry labels the PTGER3 protein in cells, allowing for visualization of its subcellular localization.
Creative Biolabs offers cell surface engineering services. The strategic functionalization of cellular membranes presents a robust avenue to augment site-specific tropism and migratory precision in therapeutic cell populations. Central to this approach is the deliberate incorporation of molecular moieties—such as ligand-receptor pairs or antibody-antigen complexes—onto the plasma membrane, thereby enabling directed migration toward defined anatomical niches.
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
