PTGER4 Membrane Protein Introduction

Introduction Related Products Customer Reviews Customized Production Drug Discovery

Introduction of PTGER4

Protein Name	Prostaglandin E receptor 4
Gene Name	PTGER4
Uniprot	P35408 (Human); P32240 (Mouse)
Synonym	EP4; EP4R; prostaglandin E2 receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostanoid EP4 receptor
Background	PTGER4, also known as Prostaglandin E2 receptor 4 or EP4, is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans. PTGER4 is able to bind prostaglandin E2 (PGE2) and mediates specific aspects of both inflammatory and regulatory eicosanoid signaling. In humans, mRNA for PTGER4 has been found by Northern blotting in the heart and small intestine and to lesser extents in lung, thymus, kidney, uterus, brain and dorsal root ganglions. Besides, PTGER4 protein is found in humans as measured via immunochemistry in pulmon.

PTGER4 Related Products

Membrane Protein Products

Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.

CAT#	Product Name	Expression System	Protein Length	Solubilizing Agents
S01YF-1023-KX397	NativeExtract™ Human PTGER4 Membrane Protein (Full length, Super Nanodisc)	HEK293 cells	Full length	Native Nanodisc
MPX3611K	MemDX™ Membrane Protein Human PTGER4 (Prostaglandin E receptor 4) Expressed in vitro E.coli expression system, Full Length	E.colicell-free	Full length	Detergent
MP0853J	MemDX™ Membrane Protein Human PTGER4 (Prostaglandin E receptor 4) for Antibody Discovery	HEK293 cells	Full length	N/A
MP1059X	MemDX™ Membrane Protein Human PTGER4 (Prostaglandin E receptor 4) with N-GST tag for Antibody Discovery	Wheat germ cell -free	Full length	N/A
MP1058X	MemDX™ Membrane Protein Human PTGER4 (Prostaglandin E receptor 4) without tag for Antibody Discovery	Wheat germ cell -free	Full length	Liposome
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Customer Reviews

J**n: I had a great experience purchasing the PTGER4 protein from Creative Biolabs. It worked perfectly in my assays, and I was able to achieve consistent results. The technical support team was also very knowledgeable and provided valuable insights.

21/ Sep/2023

Customized Membrane Protein Production

Different membrane protein formats (Creative Biolabs Original)

PTGER4 Drug Discovery and Development

PTGER4 Small Molecule Drug Development

Small molecule drug development services (Creative Biolabs Original)

Anti-PTGER4 Antibody Discovery

Processes of antibody discovery (Creative Biolabs Original)

PTGER4 Gene Therapy Development

We provide tailored solutions to meet your specific requirements. Please inquire us for more services.

Vector-Mediated Gene Delivery

Creative Biolabs offers vector-mediated gene delivery services. Engineered adenoviral platforms, AAV constructs, and lentiviral architectures are frequently employed for their divergent tropisms and integration profiles. These modular vectors can be tailored to encapsulate therapeutic transgenes, such as PTGER4, through precise molecular redesign. In contrast, non-viral delivery modalities present distinct advantages, including reduced immunogenic responses and scalable synthesis protocols. Liposomal assemblies and polymeric nanoparticles, for instance, serve as versatile alternatives, circumventing viral-associated risks. Surface functionalization of these particles with ligand moieties enhances specificity by exploiting receptor-ligand interactions at target cell membranes. Critical to both paradigms is the balance between delivery precision and biocompatibility. Speculative advancements in hybrid vector design—merging viral infectivity with synthetic stealth properties—could bridge this dichotomy, though translational hurdles persist. Current methodologies thus prioritize context-dependent selection, guided by therapeutic objectives and target tissue microenvironments.

Induced Pluripotent Stem Cells Gene Therapy

Creative Biolabs offers induced pluripotent stem cells gene therapy research services. Induced pluripotent stem cells (iPSCs) are created by reprogramming mature somatic cells, like dermal fibroblasts, into a pluripotent state. iPSCs share comparable characteristics with embryonic stem cells (ESCs) and can be applied in gene-based therapies. The key benefit of iPSCs is that they can be obtained from the patient's very own cells, which minimizes the likelihood of immune-related rejection. The PTGER4 gene can be introduced into iPSCs. Subsequently, these genetically modified iPSCs can be directed to differentiate into specific cell types for self-derived (autologous) transplantation.

PTGER4 Cell Therapy Discovery

Creative Biolabs offers comprehensive and innovative services to drive the development of PTGER4 cell therapy. Please inquire with us for more services.

Gene Silencing and Overexpression

Creative Biolabs offers gene silencing and overexpression services. Expression vectors can be constructed to silence or overexpress PTGER4. Lentiviruses are generated by co-transfecting the recombined destination vectors with the packaging mix into 293FT cells. Stable cell lines are generated by in vitro transduction with the lentiviral particles, followed by selection of GFP+ cells or using other selection methods. The expression of PTGER4 in stable cell lines is verified by qPCR and immunoblotting.

Animal Models

Creative Biolabs offers animal model production services. Cells with different PTGER4 expression levels can be intravenously injected into mice to study tumor development. For example, A20 stable cell lines with silenced or overexpressed PTGER4 are injected into BALB/c mice, and tumor development is followed over a period of 120 days.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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