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ACE

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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Background

The angiotensin-converting enzyme (ACE) is a zinc-dependent peptidase of 90 to 200 kDa that adsorbs to the outer leaflet of the endothelial plasma membrane and then is shed in a soluble form into the circulation. ACE is also a bradykinin inactivator and an enkephalinase. This places ACE at the junction of regulation of vascular tone, hemostatic balance, and nociception. ACE is concentrated in capillaries of the lung, proximal tubules of the kidney, and circumventricular organs in the brain, but its mRNA can also be induced in macrophages in sterile inflammatory settings. As such, it has been suggested to have broader roles. Different mutations of the ACE gene particularly the insertion/deletion variant impact endurance abilities as well as the development of diabetic nephropathy and responses to SARS-CoV-2 infection. Pathologies such as myocardial fibrosis and cerebrovascular remodeling occur due to ACE overactivity while ACE down-regulation leads to refractory hypotension in septic patients. ACE inhibitors and newer dual ACE-NEP inhibitors thus remain mainstays of treatment and PET tracers and ACE-targeted protein chimeras are being explored for their potential to image pulmonary endothelial damage or deliver payloads to activated macrophages.

Fig.1 The RAS and ACE axis. (OA Literature)Fig.1 The RAS and ACE2/angiotensin/MAS axis.1

ACE Protein Function: A Central Node in Cardiovascular and Metabolic Control

ACE performs multiple functions beyond blood pressure control and researchers still lack full knowledge of its molecular basis:

  • Angiotensin-Dependent Neuronal Plasticity: ACE regulates Ang I-Ang II conversion at key brain sites within the angiotensinergic system to synchronize synaptic plasticity with stress response and cognitive processing.
  • Immunometabolic Regulation: Macrophages and dendritic cells which express ACE generate Ang II directly at the site of tissue inflammation while simultaneously managing chemokine secretion and directing the differentiation of T-cells.
  • Endothelial Oxidative Stress: Membrane-bound ACE has recently been proposed to serve as an anchoring protein for NADPH oxidase subunits, which in turn may control mitochondrial ROS efflux, thus determining endothelial cell fate (survival/death). ACE and mitochondrial quality-control machinery interactions constitute an intensely studied field with implications for cardio-renal protection.

ACE Membrane Protein Product

Creative Biolabs offers a premium portfolio of native-conformation ACE membrane proteins, crucial for high-resolution structural biology and RAAS-focused drug-discovery programs. Powered by our proprietary MemDX™ Recombinant Membrane Protein platform, ACE is produced in multiple formats—mammalian VLPs, nanodisc-embedded fractions, and optimized E. coli lysates—to satisfy every experimental demand. Rigorously validated reagents that have been optimized for many biological assays. Our bullet-proof reagents are helping researchers to unravel the details of ACE-mediated peptide processing and are being leveraged to speed next-generation cardiovascular therapeutics forward.

ACE Membrane Protein Product

Not finding the membrane protein product you need? Contact us to start your one-stop custom service!

ACE Stable Cell Line Product

Engineering physiologically relevant cellular systems is pivotal for advancing ACE-centered cardiovascular and neuro-immunological studies. Creative Biolabs therefore delivers bespoke, high-expression ACE stable cell lines—generated through our proprietary MemDX™ Cell-Line Engineering Suite—that preserve native membrane topology and full enzymatic activity. The stable cell lines we offer offer assurance of uniform ACE density, correct sub-cellular localization and a low level of background activity. This allows for a reproducible and scalable tool for the interrogation of ACE driven RAAS signaling, profiling of anti-hypertensive antibodies and to support the development of new generations of antihypertensive drugs, speeding up your discovery process from target validation to lead optimization.

ACE Membrane Protein Product

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Not finding the stable cell line product you need? Contact us to start your one-stop custom service!

ACE Recombinant Antibody Product

Expand your ACE research toolkit with Creative Biolabs’s premium collection of high-affinity recombinant antibodies engineered against the full-length, correctly folded angiotensin-converting enzyme. Each antibody is pre-validated for Western Blot (WB), Direct ELISA & in-plate activity assays, Flow cytometry (FCM) of live/endothelial cells, High-resolution immunofluorescence (IF) & confocal IC, Paraffin and frozen tissue IHC, Immunoprecipitation (IP) followed by enzymatic or MS read-outs. Whether you are mapping ACE micro-domains, quantifying membrane-bound versus soluble isoforms, or tracking inhibitor-induced internalization, our recombinant reagents provide reproducible, publication-ready data, empowering precise dissection of ACE biology in cardiovascular, pulmonary, and neuro-immune research.

TSPO Recombinant Antibody Product

Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!

Product Features

  • High Purity & Activity: Rigorous quality control ensures optimal performance.
  • Choice of Expression Platforms: Need native glycosylation? Pick HEK293. Prefer cost-effective screening? Select E. coli. Want native membrane display? Order VLP-embedded ACE—all from the same master clone.
  • Wide Species Coverage: Commercially available ready to use diverse ACE variants. Orthologs and point-mutants available on demand.
  • Assay-Ready Validation: Demonstrated performance in diverse immunological and biochemical assays.
  • Ultra Consistent Quality: Minimizes variability in experiments.
  • Customization Options: Can be provided with custom tags, endotoxin removal, biotinylation, dye-labeling or nanodisc reconstitution (with project-specific QC packages).

Custom ACE Membrane Protein & Antibody Discovery Solutions

  • Custom ACE Protein Expression Services: Tailored expression, purification, and characterization of challenging ACE membrane proteins .
  • Custom Antibody Development: From antigen design to antibody engineering (monoclonal, polyclonal, recombinant) for specific research or therapeutic applications.
  • Stable Cell Line Development: Generation of bespoke stable cell lines expressing your target of interest.
  • Functional Assay Development: Designing and executing assays to assess protein function and ligand binding.

Frequently Asked Questions (FAQ)

  1. Why is ACE a high-priority research target?

    A1: ACE is a major control point for blood-pressure homeostasis and inflammatory pathways that cause fibrosis. It is a validated drug target for treatment of hypertension and heart failure. Genetic variants such as the I/D variant are used to predict cardiovascular risk and drug response.

  2. Q2: What is the main activity of ACE?

    A2: ACE degrades angiotensin I into angiotensin II and degrades the vasodilator bradykinin. Ang II and BK degradation together result in hypertension and vascular changes.

  3. Q3: Are Creative Biolabs’s ACE proteins/antibodies approved for clinical use?

    A3: No—every ACE reagent, cell line, or assay service is strictly “Research Use Only” and is not intended for diagnosis, prevention, treatment, or cure of any human disease.

  4. Q4: Can Creative Biolabs generate custom ACE stable cell lines or assay cascades?

    A4: Yes, all services can be customized to your specific requirements.

Reference
  1. Ni, Wentao, et al. "Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19." Critical Care. 24.1 (2020): 422. Under Open Access license CC BY 4.0, without modification. To it: No follow https://doi.org/10.1186/s13054-020-03120-0
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