pBOOST3-mTBK1 (VCar-Ly037)
Expresses the mouse TANK-binding kinase 1 (TBK1) gene.
Type
Dendrimers&Cyclopeptides
Applications
For DNA vaccine delivery.
Introduction
pBOOST3-mTBK1 plasmid expresses the mouse TANK-binding kinase 1 (TBK1) gene and contains the EF-1α/HTLV composite promoter coupled to the SV40 enhancer. TBK1 is a non-canonical IkB kinase and was shown to mediate the adjuvant effect of DNA vaccines. DNA vaccination induces the production of type I interferons and inflammatory cytokines in a CpG-independent manner but in a TBK1-dependent manner. Thus, co-administration of a TBK1-expressing plasmid is expected to further boost DNA vaccine-induced immunogenicity.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.