Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCreative Biolabs is one of the first-in class global manufacturers of antibodies and is professional in producing all kinds of antibodies. Based on our advanced phage display techniques and rich experiment, we have developed a full package of premade phage display libraries, which enables us to offer best-in-field phage display library screening service against specific targets. Especially, our scientists have help global researchers screened numerous antibodies for immunotherapy development, which including but not limited to immune checkpoint.
Immune checkpoints, which consist of both stimulatory and inhibitory pathways, are important immune regulators in maintaining immune homeostasis and preventing autoimmunity. Under normal circumstances, immune checkpoints allow the immune system to respond against infection and malignancy while protecting tissues from any harm that may derive from this action. However, the expression of some of these immune-checkpoint proteins by malignant cells dysregulates the antitumor immunity and favors the growth and expansion of cancer cells. Over the past decade, immune checkpoint therapy has emerged as a new pillar of cancer treatment and provides renewed hope for reducing morbidity and mortality of this complex disease. Currently, monoclonal antibodies targeting many inhibitory pathways, such as cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), programmed cell death receptor-1 (PD-1), and programmed cell death ligand-1 (PD-L1), have been developed as immune checkpoints inhibitors for cancer therapy.
Fig.1 A scheme of mechanisms of peptide vaccine therapy and immune checkpoint inhibition therapy. (Akazawa, 2019)
At present, all the approved checkpoint inhibitors are monoclonal antibodies produced by hybridoma and engineering technology. Recently, phage display biopanning provides a high throughout tool to identify potential antibody candidates against a wide variety of molecular targets. As a leading company in the field of antibody production, Creative Biolabs has developed multiple phage displayed antibody libraries with overwhelming capacity and diversity. Our professional scientists are confident in screening impeccable antibodies with high affinity ranging from pM to nM in the formats of scFv, Fab, and sdAb. The premade phage displayed antibody libraries available at Creative Biolabs include:
| Libraries | Library ID | Display Technology | Library Format | Species | Library Size |
| Phage display human scFv libraries | HuScL-2 | Phage Display | scFv | Human | 1.42×109 |
| HuScL-4 | Phage Display | scFv | Human | 2.0×109 | |
| HuScL-6 | Phage Display | scFv | Human | 1.0×1011 | |
| HuScL-7 | Phage Display | scFv | Human | 1.1×1010 | |
| Phage display human Fab libraries | HuFabL-4 | Phage Display | Fab | Human | 1.9×1010 |
| HuFabL-5 | Phage Display | Fab | Human | 1.1×1010 | |
| HuFabssL-1 | Phage Display | Fab | Human | 1.8×1010 |
Creative Biolabs also provides antibody discovery services for different types of targets to suit a variety of applications:
Creative Biolabs is dedicated to tailoring the most suitable premade antibody library screening service according to special custom demands and expectations. For more detailed information about how we can aid your project, please feel free to contact us.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
