Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe CaVHHL-5 Camel Naïve sdAb Library is a cutting-edge resource for high-quality antibody screening. Featuring a diverse array of camel-derived naïve single-domain antibodies (sdAbs), this library is optimized for discovering high-affinity binders to your target proteins. Designed to support both research and commercial applications, it ensures reliable and reproducible results that accelerate your research progress.
| Species | Camel | Library ID | CaVHHL-5 |
| Display Technology | M13 pIII fusion, Phagemid phage display system | Library Format | Naïve VHH |
| Vector System | pMECS | Tags | His, HA tag |
| Library Capacity | 3.0×1010 | Library Source | Collections of antibody genes from several none immunized camels |
| Host Strain |
TG1 cells for proliferation HB2151 cells for antibody production |
Helper Phage | M13KO7 |
|
Unique Camel Antibody Source The CaVHHL-5 Library contains an extensive assortment of naïve sdAbs extracted from camels without immunization. Small sized sdAbs display high stability and strong specificity which enables them to attach to challenging targets that conventional antibodies find difficult. |
Broad Target Compatibility The library performs exceptionally well across various targets including membrane proteins, hidden antigens and low-immunogenic targets and so proves to be perfect for research and therapeutic development. |
|
Unmatched Screening Performance and Proven Success The CaVHHL-5 Library consistently provides exceptional antibody screening results by accurately identifying high-affinity binders with reliability. The library's established success makes it dependable for tackling difficult research objectives while delivering consistent quality results for multiple target types. |
High Specificity & Stability SdAbs from camels stand out for their exceptional ability to bind challenging epitopes and complex targets while maintaining high specificity and stability across different conditions. These antibodies prove perfect for confronting binding difficulties in multiple applications. |
Describe your target including proteins, peptides, small molecules or cell-based targets and list any special screening requirements you have.
We use the CaVHHL-5 library and phage display technology to quickly screen for high-affinity binders, ensuring that only the most promising candidates are identified.
After screening, we provide you with a detailed report, including the best candidate sequences, their binding affinity, and specificity.
Our team provides assistance for every stage of the process while delivering necessary guidance and support which helps you achieve success.
Note: We provide screening-only services without providing enriched libraries after several screening rounds. Our focus is on providing you with high-quality screening results tailored to your specific targets.
Our screening services provide a full spectrum of options designed to address the specific requirements of your research endeavors. We provide expertise in multiple antibody types and target categories such as:
| Target: | |||
| Membrane Protein Targets | Cell-based Targets | Enzyme Inhibitors | MHC-Peptide Complexes |
| Disease and Biomarker Targets: | Viral Antigens | Cancer Antigens | Receptor Targets |
| Small Molecule Targets | Toxin Targets | ||
| Antibody: | |||
| Bispecific Antibodies | Anti-Idiotype Antibodies | Cell-Internalizing Antibodies | Anti-Epitope Antibodies |
| Case: Screening for Cross-Reactive sdAbs | |
| Starting Materials |
Target protein T1 Target protein T2 Unrelated control protein C1 |
| Solid-Phase Screening Strategy |
Pre-counter selection using control C1 Positive selection alternating between target T1 and target T2 |
| Key Results |
  After four rounds of screening and validation using phage ELISA, we successfully identified three clones that exhibited cross-reactive binding to both T1 and T2. Further testing confirmed that two of these clones were highly specific, with no binding to the unrelated control protein C1, ensuring reliable and targeted results for the clients' research. |
In addition to the CaVHHL-5 Library, Creative Biolabs offers a broad range of premade sdAb antibody libraries from various sources, including llama, alpaca, and humanized libraries. These libraries are designed to meet the needs of both researchers and therapeutic developers, providing flexibility and specificity for diverse applications.
| Antibody Library ID | Display Technology | Library Format | Library Size | Out-licensing |
| CaVHHL-4 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 2.63×1010 | Screening-only |
| CaVHHL-5 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 3.0×1010 | Screening-only |
|
CaVHHL-6 ⚡️ Hot Product |
pIII-fusion, Phagemid Phage Display | Naïve VHH | 2.43×109 | ✔️ |
|
CaVHHL-S2 ⭐️ Premium Selection |
pIII-fusion, Phagemid Phage Display | Synthetic VHH | 5.4×1010 | Screening-only |
| CaVHHL-S3 | pIII-fusion, Phagemid Phage Display | Synthetic VHH | 2.2×1010 | Screening-only |
| CaVHHL-S4 | pIII-fusion, Phagemid Phage Display | Semi-synthetic VHH | 5.3×1010 | Screening-only |
to accelerate your antibody discovery by requesting a quote! Let our team support you in achieving your research milestones efficiently and effectively.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
