Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe Phage Display AlVHHL-2 Alpaca Single Domain Antibody Library excels due to its vast library size and significant genetic variety produced from multiple alpacas. The combination of broad genetic diversity and single-domain antibodies delivers precise solutions for complex scientific challenges that standard antibody libraries find difficult to address. Our extensive library offers numerous selections which allow for swift detection of highly specific, stable antibodies to boost your therapeutic development process.
| Species | Alpaca | Library ID | AlVHHL-2 |
| Display Technology | M13 pIII fusion, Phagemid phage display system | Library Format | Naïve VHH |
| Vector System | pMECS | Tags | HA, His tag |
| Library Capacity | 1.5×1011 | Library Source | Collections of antibody genes from 196 none immunized alpacas |
| Host Strain |
TG1 cells for proliferation HB2151 cells for antibody production |
Helper Phage | M13KO7 |
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High Capacity and Diversity With a vast genetic pool from ~200 non-immunized alpacas, the AlVHHL-2 Library offers unmatched diversity, ensuring access to high-quality, specific antibodies ideal for complex targets and challenging antigens. |
Naïve and Unbiased Antibodies Derived from non-immunized alpacas, our library provides naïve and unbiased antibodies, maximizing the potential for discovering novel, highly specific candidates across a wide range of applications, from drug discovery to diagnostics. |
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Unique Single-Domain Characteristics Alpaca-derived sdAbs are small, stable, and highly specific, offering superior tissue penetration and low immunogenicity. Their robust performance makes them perfect for targeting difficult antigens in therapeutic and diagnostic applications. |
Advanced Phage Display Technology Using the M13 pIII fusion system and phagemid-based vector, the library ensures high stability and high-affinity binding, supporting high-throughput screening for rapid identification of the best antibody candidates. |
Creative Biolabs offers high-efficiency antibody screening using the AlVHHL-2 Alpaca Single Domain Antibody Library, ideal for both exploratory and high-throughput projects. Backed by a highly diverse library and expert selection strategies, we identify validated single-domain antibodies with exceptional specificity, affinity, and stability - tailored to your unique targets. From complex proteins to low-immunogenic antigens, we streamline antibody discovery so you can focus on driving innovation forward.
Our AlVHHL-2 Library can be used to screen antibodies against a wide variety of targets, including but not limited to:
| Antibody Types: | |||
| Bispecific Antibodies | Anti-Idiotype Antibodies | Anti-Epitope Antibodies | Cell-Internalizing Antibodies |
| Target Types: | |||
| Membrane Protein Targets | Cell-based Targets | Enzyme Inhibitors | MHC-Peptide Complexes |
| Disease and Biomarker Targets: | Pathogen antigens | Cancer Antigens | Receptor Targets |
| Small Molecule Targets | Toxin Targets | ||
Creative Biolabs delivers a fully managed, high-efficiency antibody screening service powered by the AlVHHL-2 Alpaca sdAb Library. Our streamlined process is tailored to meet the specific demands of each project, ensuring you receive high-affinity, stable, and target-specific sdAbs with speed and reliability.
Start by providing us with key details about your target.
Based on your target type and project goals, our team of experts will design a customized phage display screening strategy. Every step is aligned with your intended application to maximize discovery success and project relevance.
Using the ultra-diverse AlVHHL-2 Library, we conduct iterative phage display screening to enrich high-quality binders. The large diversity of the library enables identification of rare, high-affinity, and stable antibodies, even against difficult or low-immunogenic targets.
Promising antibody candidates are validated using multiple assays, ensuring high specificity and binding affinity. We also could provide detailed data on binding kinetics, thermal stability, and functional performance, helping you confidently advance the most suitable candidates for downstream development.
You will receive a full screening report including validated VHH sequences and optional guidance for further expression or application. Our team offers continuous technical support throughout the project to ensure smooth execution and scientific success.
Note: We offer screening-only services and do not provide enriched libraries. Our focus is on delivering ready-to-use, fully validated antibody candidates tailored to your target.
| Case: Screening for CNS Disease-Related Target | |
| Objective | To identify high-affinity, specific sdAbs against a central nervous system (CNS) disease-associated peptide target (T1), while eliminating cross-reactivity with a structurally similar control peptide (C1). |
| Starting Materials |
Target peptide: T1 (CNS disease-related epitope) Control peptide: C1 (closely related, non-pathogenic sequence) |
| In-Solution Screening Strategy |
Pre-counter selection against peptide C1 to remove non-specific binders Positive selection for peptide T1 to enrich target-specific clones |
| Key Results |
  4 sdAb clones were isolated with high specificity for T1 and no detectable binding to C1. Top sdAb candidates exhibited high binding affinity (determined by ELISA and SPR). |
Creative Biolabs offers a comprehensive portfolio of premade sdAb libraries derived from camelids (camel, alpaca, and llama) and humanized sources, optimized for applications ranging from early target discovery to therapeutic development. In addition, we provide species-diverse libraries - including mouse, rabbit, and chicken - to support unique immunological profiles and broaden your screening options. Whether you're tackling difficult targets or seeking cross-species reactivity, our ready-to-use libraries deliver versatility, depth, and performance for a wide range of research needs.
| Antibody Library ID | Display Technology | Library Format | Library Size | Out-licensing |
| AlVHHL-1 | pIII-fusion, Phagemid Phage Display | Naïve VHH | 1.35×1010 | ✔️ |
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AlVHHL-2 �� Highly Recommended |
pIII-fusion, Phagemid Phage Display | Naïve VHH | 1.5×1011 | Screening-only |
for a personalized quote tailored to your project requirements. Our team will work closely with you to understand your goals and show how the AlVHHL-2 library can accelerate your antibody discovery and elevate your research outcomes. Let us help you move forward - efficiently, precisely, and with confidence.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
