shRNA Adeno-associated Virus Serotype 2, pH1-(SPAM1-shRNA-Seq2)(CAT#: AAV-SI2357WQ)

This product is a SPAM1-shRNA encoding AAV, which is based on AAV-2 serotype. The SPAM1 gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. The expression of SPAM1-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.