Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCystic fibrosis transmembrane conductance regulator (CFTR) is also known as ATP-binding cassette sub-family C member 7, channel conductance-controlling ATPase or cAMP-dependent chloride channel. The CFTR gene encodes a cAMP-regulated chloride channel protein present in the apical membrane of epithelial cells. CFTR follows the same domain structure as other ABC transporters: two nucleotide-binding domains (NBD) in tandem with two transmembrane domains (TMD). It differs from other transporters by its regulatory region or 'R' region. The R region is located between the first TMD and the second NBD within the cytoplasm.
| Basic Information of CFTR | |
| Protein Name | Cystic fibrosis transmembrane conductance regulator |
| Gene Name | CFTR, ABCC7 |
| Aliases | ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, cAMP-dependent chloride channel |
| Organism | Homo sapiens (Human) |
| UniProt ID | P13569 |
| Transmembrane Times | 12 |
| Length (aa) | 1480 |
| Sequence | MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL |
CFTR is unique among ABC transporters because it is the only member of the membrane protein family to act as an ion channel member. CFTR was originally thought to be specifically expressed by epithelial cells. However, recent studies have shown that CFTR is expressed in neurons of human central nervous system, including the brain and spinal cord. In addition, the widespread presence of CFTR has been demonstrated in the peripheral nervous system, including the human spinal cord, sympathetic nerves, and cervical ganglia. These findings suggest that CFTR plays an important role in the physiology of the central and peripheral nervous systems. CFTR may participate in neuronal physiology through several mechanisms, with the most important of which is: maintaining intracellular electrolyte homeostasis, regulating membrane recycling, modulating membrane traffic, governing the efflux of glutathione, regulating neuropeptide secretion, and acting as a neuromodulator and cell signaling molecule.
Fig.1 Homology models for CFTR. (Meng, 2017)
This study found an important role of CFTR in mediating RA-dependent signaling in stem cell differentiation and embryo development.
This article revealed that CFTR had been reported to affect individual susceptibility to chronic pancreatitis (CP). F508 deletion in CFTR was a risk factor for CP, while Indians with F508 deficiency had much higher CP morbidity.
This article verified that Dexamethasone could induce a rapid stimulation of CFTR activity, which was dependent on PI3K/AKT signaling in airway epithelial cells.
The results showed that CFTR was down-regulated in nasopharyngeal carcinoma (NPC) tissues and cell lines, and that low expression levels of CFTR were associated with cancer progression and poor survival in NPC patients. Furthermore, this study demonstrated that CFTR manipulation in NPC cell lines affected cell migration and invasion and provided a molecular basis for the role of CFTR in NPC development.
This study of gastrointestinal samples revealed extensive expression of CFTR in the intestinal ganglia, suggesting that CFTR may play a role in the physiology of the innervation of the gastrointestinal tract.
Membrane protein studies have advanced significantly over the past few years. Based on our versatile Magic™ membrane protein production platform, we could offer a series of membrane protein preparation services for worldwide customers in reconstitution forms or membrane protein mutants. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CFTR antibody development services.
During the past years, Creative Biolabs has successfully generated many functional membrane proteins for our global customers. We are happy to accelerate the development of our clients’ programs with our one-stop, custom-oriented service. For more detailed information, please feel free to contact us.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
