Introduction of FZD2
FZD2 is encoded by the FZD2 gene. It belongs to the G-protein-coupled receptor (GPCR) family which has been largely studied in the past few decades. It presents numerous possibilities for various therapeutic applications. It is one of the ten subtypes of frizzled family (FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10). FZD2 is a seven-transmembrane domain protein with the length of 565 amino acids.
|Basic Information of FZD2|
|Aliases||Fz2, fz-2, fzE2, hFz2|
|Organism||Homo sapiens (Human)|
Function of FZD2 Membrane Protein
Frizzled is a family of G-protein-coupled receptor (GPCR) proteins which has been served as receptors in various signaling pathways, such as Wnt signaling pathway. FZD2 belongs to the Frizzled family and plays key roles in cell proliferation, governing cell polarity, the formation of neural synapses, embryonic development, and some other processes in developing and adult organisms. Among all FZD subtypes, secreted Frizzled-related protein 1 (SFRP1) is able to interact with FZD2 so that guide growth cone movement. In addition, the disease associated with FZD2 include Omodysplasia and Omodysplasia 2. In recent years, several studies have shown that FZD2 enables the tumor biology regulation in a complex manner and gene FZD2 might inhibit cell growth and migration in various tumor types.
Fig.1 Structure of FZD2 membrane protein.
Application of FZD2 Membrane Protein in Literature
This article reports that both NXN and FZD2 are relevant protein partners in the WNT5A interactome and play important roles in skeletal development. The genetic heterogeneity of robinow syndrome is based on WNT signaling perturbations.
This article reveals that the heterozygous nonsense FZD2 mutation impairing Wnt signaling and induces the OMOD2 or Robinow syndrome-like phenotype. The FZD2 mutation has been identified in a family with AD omodysplasia.
This article reports that the changes of FZD2 mRNA expression in a certain time after contusion might be a basis to estimate wound age by combined multi-indicators.
This article reveals that the FZD2 regulates tumor biology in a complex manner. This research suggests that FZD2 might be a tumor suppressor gene inhibits cell growth and migration in SACCs.
FZD2 Preparation Options
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