Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Frizzled class receptor 2 |
| Gene Name | FZD2 |
| Uniprot | Q14332 (Human); Q9JIP6 (Mouse) |
| Synonym | Fz2; fz-2; fzE2; hFz2; OMOD2; frizzled-2; frizzled 2, seven transmembrane spanning receptor; frizzled family receptor 2; frizzled homolog 2 |
| Background | FZD2 is encoded by the FZD2 gene. It belongs to the G-protein-coupled receptor (GPCR) family which has been largely studied in the past few decades. It presents numerous possibilities for various therapeutic applications. It is one of the ten subtypes of frizzled family (FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10). FZD2 is a seven-transmembrane domain protein with the length of 565 amino acids. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX270 | NativeExtract™ Human FZD2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3625K | MemDX™ Membrane Protein Human FZD2 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MPX0025K | MemDX™ Membrane Protein Human FZD2 (Frizzled class receptor 2) Expressed in Mammalian Cell for Antibody Discovery, Partial (29-168aa) | Mammalian cell | Partial | N/A |
| MP0119F | MemDX™ Antibody Discovery - Human Frizzled-2 / FZD2 (24-156) Membrane Protein, Partial, -hIgG1 Fc tag | HEK293 cell | Partial | N/A |
| MP0118F | MemDX™ Antibody Discovery - Human Frizzled-2 / FZD2 (24-190) Membrane Protein, Partial, -hIgG1 Fc tag | HEK293 cell | Partial | N/A |
| Please for more products or customization | ||||
S***n: Their tailored FZD2 variants with C-terminal tags retained full bioactivity in cryo-EM studies.
23/Aug/2023
L***an: The technical team provided detailed membrane reconstitution protocols within 72 hours.
18/Feb/2024
FZD2 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
FZD2 Silencing for Oncological Intervention
Creative Biolabs offers FZD2 silencing services. Gene editing enables precise disruption of FZD2, a Wnt signaling receptor overexpressed in hepatocellular carcinoma (HCC) and gliomas. For instance, siRNA-mediated FZD2 knockdown in HCC models reduces tumor proliferation and epithelial-mesenchymal transition (EMT). Similarly, gene interference in glioma cells blocks the Notch/NF-κB pathway, impairing vasculogenic mimicry and tumor stemness. Such strategies highlight the potential for FZD2-targeted genome editing to mitigate oncogenic signaling cascades.
Adeno-Associated Virus (AAV)-Driven FZD2 Overexpression for Tissue Regeneration
Creative Biolabs offers AAV-driven FZD2 overexpression services for tissue regeneration. AAV vectors engineered for tissue-specific FZD2 delivery can enhance regenerative pathways in chronic diseases. Preclinical studies demonstrate that FZD2 overexpression in hepatic progenitor cells activates β-catenin signaling, promoting tissue repair in fibrotic liver models. Creative Biolabs' expertise in viral vector design ensures optimized tropism and safety profiles for such applications, mirroring methodologies previously validated in Parkinson's disease models with FZD2-targeted vectors.
RNA Interference (RNAi) for Metastasis Suppression
Creative Biolabs offers RNA interference services. Lentiviral short hairpin RNA (shRNA) constructs targeting FZD2 effectively reduce metastasis in breast cancer models, as shown by diminished colony formation in clonogenic assays and apoptosis induction via flow cytometry. Creative Biolabs' shRNA libraries and in vivo validation platforms, including orthotopic xenografts, streamline translational development of these therapies.
Creative Biolabs offers comprehensive and innovative services to drive the development of FZD2 cell therapy. Please for more services.
CAR-T Cells Engineered to Target FZD2-Expressing Tumors
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells targeting FZD2 surface epitopes show promise in solid tumors. For example, FZD2-specific CAR-T constructs lyse glioma cells by recognizing overexpressed FZD2, as quantified by cytotoxicity assays and reduced tumor volume in murine models. Creative Biolabs' immunofluorescence-based FZD2 expression profiling ensures precise target validation for CAR-T development.
Mesenchymal Stem Cell (MSC)-Mediated FZD2 Pathway Modulation
Creative Biolabs offers MSC-mediated FZD2 pathway modulation services. MSCs modified to secrete FZD2-decoy receptors inhibit Wnt signaling in the tumor microenvironment. In HCC, these cells reduce angiogenesis and EMT, as evidenced by downregulated VEGF and MMP-9 in immunofluorescence imaging. Creative Biolabs' imaging pipelines, including super-resolution microscopy, enable real-time tracking of MSC tropism and therapeutic efficacy.
Tumor-Infiltrating Lymphocyte (TIL) Expansion with FZD2 Checkpoint Inhibition
Creative Biolabs offers TIL expansion with FZD2 checkpoint inhibition services. Combining TIL therapy with FZD2-blocking antibodies enhances antitumor immunity in breast cancer. Preclinical data reveal synergistic suppression of TGF-β-driven EMT and Notch activation, prolonging survival in metastatic models. Creative Biolabs' genetic variation analysis services identify patient subsets most likely to benefit from this combinatorial approach.
Creative Biolabs delivers tailored platforms for FZD2 therapeutic development. Our gene expression analysis, viral vector engineering, and high-resolution imaging services ensure robust preclinical data to de-risk clinical translation. Consult us to optimize your FZD2-targeted pipeline with industry-leading expertise.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
