Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Frizzled class receptor 4 |
| Gene Name | FZD4 |
| Uniprot | Q9ULV1 (Human); Q61088 (Mouse) |
| Synonym | Fz4; EVR1; FEVR; Fz-4; FzE4; GPCR; hFz4; CD344; FZD4S; frizzled-4; WNT receptor frizzled-4; frizzled 4, seven transmembrane spanning receptor; frizzled family receptor 4; frizzled homolog 4 |
| Background | FZD4 is encoded by the FZD4 gene which belongs to the G-protein-coupled receptor (GPCR) family. In the past few decades, the GPCR family has been largely studied because of its numerous possibilities for therapeutic applications. It is one of the ten subtypes of the frizzled family (FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10). Among all FZD subtypes, FZD4 spans a total of 7392 nucleotides and encodes the protein with 537 amino acids. This protein contains seven transmembrane domains and the N-terminal cysteine-rich domain. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX465 | NativeExtract™ Human FZD4 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3614K | MemDX™ Membrane Protein Human FZD4 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MPVLP-021 | MemDX™ Recombinant Human FZD4 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cell | Full length | VLPs |
| MP0385X | MemDX™ Membrane Protein Human FZD4 (Frizzled class receptor 4) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| S01YF-0423-KX303 | MemDX™ Membrane Protein Human FZD4 (37-180aa) Expressed in HEK293, C-Human Fc tag | HEK293 cell | Partial | N/A |
| MPX0026K | MemDX™ Membrane Protein Human FZD4 (Frizzled class receptor 4) Expressed in Mammalian Cell for Antibody Discovery, Partial (37-180aa) | Mammalian cell | Partial | N/A |
| Please for more products or customization | ||||
S**e: Seamless integration with SPR platforms accelerated our therapeutic screening. Technical support ensured rapid troubleshooting—ideal for high-stakes projects.
05/May/2023
Ph***ix: Responsive customization streamlined our membrane protein workflow.
14/Dec/2023
FZD4 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
FZD4 Mutation Correction
Creative Biolabs offers FZD4 mutation correction services. Precise genome editing enables the repair of pathogenic FZD4 mutations linked to Wnt signaling dysregulation, such as those implicated in familial exudative vitreoretinopathy (FEVR). By delivering ribonucleoprotein (RNP) complexes directly into retinal progenitor cells, this method achieves high specificity in restoring FZD4 function without off-target effects. Creative Biolabs' end-to-end gene-editing platform streamlines target validation and in vitro efficacy testing for such therapeutic constructs, ensuring robust preclinical data generation.
AAV-Driven FZD4 Gene Supplementation
Creative Biolabs offers AAV-driven FZD4 gene supplementation services. Recombinant adeno-associated virus (AAV) vectors engineered with tissue-specific promoters facilitate targeted FZD4 expression in endothelial or epithelial cells. Preclinical models demonstrate that intraocular AAV9-FZD4 delivery restores vascular patterning in FEVR, highlighting its therapeutic potential. Creative Biolabs' proprietary AAV serotype library and in vivo biodistribution profiling services accelerate vector optimization for clinical translation.
siRNA Modulation of FZD4 Regulatory Networks
Creative Biolabs offers siRNA modulation of FZD4 regulatory networks services. Dual-targeting siRNA strategies silence negative regulators of FZD4, such as secreted frizzled-related proteins (SFRPs), to amplify Wnt/β-catenin signaling in bone regeneration therapies. This approach enhances osteoblast differentiation in mesenchymal stem cells, offering promise for osteoporosis treatment. Creative Biolabs' siRNA design and delivery platforms ensure >90% knockdown efficiency with minimal immunogenicity.
Creative Biolabs offers comprehensive and innovative services to drive the development of FZD4 cell therapy. Please for more services.
FZD4-Overexpressing Mesenchymal Stem Cell (MSC) Implants
Creative Biolabs offers FZD4-overexpressing MSC implant development services. MSCs engineered to overexpress FZD4 via lentiviral transduction exhibit enhanced angiogenic capacity in ischemic tissue models. These cells secrete Wnt ligands to stimulate endogenous vascular repair, making them viable for myocardial infarction therapy. Creative Biolabs' cell line development services ensure scalability and regulatory compliance for clinical-grade production.
Chimeric Antigen Receptor (CAR) T Cells Targeting FZD4-Positive Tumors
Creative Biolabs offers CAR-T cells targeting FZD4-positive tumors development services. CAR-T cells designed to recognize FZD4 surface epitopes demonstrate potent cytotoxicity against colorectal cancer xenografts with minimal off-tumor effects. This strategy exploits FZD4's role in cancer stem cell maintenance, offering a novel immunotherapeutic avenue. Creative Biolabs' CAR-T cytotoxicity assays and cytokine release profiling platforms enable rapid therapeutic candidate screening.
3D Bioprinted Tissues with Spatiotemporal FZD4 Expression
Creative Biolabs offers 3D bioprinted tissues development services. Bioprinted constructs incorporating FZD4-expressing stromal cells recapitulate tissue-specific Wnt signaling gradients for cartilage regeneration. Layer-specific FZD4 activation in these constructs promotes chondrocyte proliferation and matrix deposition, addressing osteoarthritis pathology. Creative Biolabs' bioprinting and organoid validation services support complex tissue model development.
Leverage our end-to-end expertise in gene editing, viral vector engineering, and cell therapy development to accelerate your FZD4-targeted programs. to design a customized strategy aligned with your therapeutic goals.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
