Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Frizzled class receptor 5 |
| Gene Name | FZD5 |
| Uniprot | Q13467 (Human); Q9EQD0 (Mouse) |
| Synonym | HFZ5; C2orf31; frizzled-5; Wnt receptor; frizzled 5, seven transmembrane spanning receptor; frizzled family receptor 5; fz-5; fzE5; seven-transmembrane receptor frizzled-5 |
| Background | The Frizzled-5 (FZD5) protein, a pivotal component within the intricate landscape of cellular communication, is recognized as a member of the frizzled receptor family, characterized by its distinctive seven-transmembrane helical structure. In humans, the FZD5 gene encodes this particular receptor, positioning it among the ten identified subtypes that comprise the broader frizzled family (FZD1-FZD10). Importantly, FZD5 is concurrently classified within the expansive superfamily of G-protein-coupled receptors (GPCRs). Recent advancements in molecular biology and pharmacology have underscored the significant therapeutic promise inherent in GPCRs, thereby rendering them subjects of intensive investigative efforts. Furthermore, accumulating evidence indicates that the FZD5 protein functions as the cognate receptor for the WNT5A ligand. This interaction is not merely an academic curiosity; rather, it appears to be a crucial determinant in the complex biological process of angiogenesis, potentially regulating the formation of new blood vessels. Perhaps, further elucidation of this intricate interplay could yield novel insights into vascular development and disease pathologies. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX268 | NativeExtract™ Human FZD5 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX3632K | MemDX™ Membrane Protein Human FZD5 Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| MP0386X | MemDX™ Membrane Protein Human FZD5 (Frizzled class receptor 5) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MPX0027K | MemDX™ Membrane Protein Human FZD5 (Frizzled class receptor 5) Expressed in Mammalian Cell for Antibody Discovery, Partial (27-167aa) | Mammalian cell | Partial | N/A |
| MP0120F | MemDX™ Antibody Discovery - Human Frizzled-5 / FZD5 (27-167) Membrane Protein, Partial, -hIgG1 Fc tag | HEK293 cell | Partial | N/A |
| Please for more products or customization | ||||
E***ys: Accelerated 4-week delivery facilitated uninterrupted receptor-ligand interaction experiments.
27/Sep/2023
T***ra: Creative Biolabs' engineered FZD5 variants exhibited preserved structural integrity across thermal/pH cycles.
13/Aug/2024
FZD5 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
FZD5 Knockout for Wnt Pathway Modulation
Creative Biolabs offers FZD5 knockout services for Wnt pathway modulation. Gene-editing technologies now afford unprecedented precision in molecular intervention, enabling the targeted perturbation of specific genes. In this context, the precise disruption of the Frizzled-5 (FZD5) gene presents a compelling strategy for mitigating aberrant Wnt/β-catenin signaling, a molecular hallmark frequently observed in both colorectal and hepatocellular carcinomas. To achieve this, platforms developed by Creative Biolabs leverage meticulously engineered single-guide RNAs designed to target exons encoding the crucial extracellular cysteine-rich domain of FZD5.
AAV-Driven FZD5 Overexpression for Tissue Regeneration
Creative Biolabs offers AAV-driven FZD5 overexpression services. The targeted augmentation of Wnt-mediated vascular repair pathways presents a compelling therapeutic avenue for various pathologies. To this end, adeno-associated virus (AAV) vectors, meticulously engineered with tissue-specific promoters, enable the localized overexpression of the FZD5 gene. This precision gene delivery system is designed to selectively enhance the Wnt signaling cascade within specific tissues. Creative Biolabs has demonstrated the remarkable efficacy of its comprehensive AAV serotype library in this regard.
siRNA-Based FZD5 Silencing for Fibrotic Disease Intervention
Creative Biolabs offers siRNA-based FZD5 silencing services. The precise and sustained silencing of specific gene targets represents a promising therapeutic approach for various fibrotic pathologies. To this end, Creative Biolabs has developed a sophisticated strategy employing lipid nanoparticle (LNP)-encapsulated small interfering RNA (siRNA) formulations designed to attenuate FZD5 expression. These innovative formulations achieve sustained FZD5 silencing, extending beyond 14 days, specifically within hepatic stellate cells. The functional consequence of this targeted gene knockdown is a notable suppression of collagen deposition, as robustly demonstrated in murine models of liver fibrosis.
Creative Biolabs offers comprehensive and innovative services to drive the development of FZD5 cell therapy. Please for more services.
CAR-T Cells Engineered with FZD5-Specific scFv Domains
Creative Biolabs offers CAR-T cells engineered with FZD5-specific scFv domains development services. The strategic deployment of chimeric antigen receptor (CAR)-T cells represents a transformative advance in oncology, offering highly targeted therapeutic interventions. In this context, CAR-T cells engineered to incorporate FZD5-targeting single-chain variable fragments (scFv) have demonstrated remarkable efficacy. Specifically, these modified immune cells exhibit potent cytotoxicity against FZD5-positive triple-negative breast cancer (TNBC) xenografts, resulting in a substantial reduction of tumor mass, often exceeding 80%. Creative Biolabs is at the forefront of optimizing these CAR constructs. Our services encompass meticulous affinity maturation techniques designed to mitigate the critical challenge of on-target/off-tumor binding.
FZD5⁺ Mesenchymal Stem Cells (MSCs) for Osteogenic Differentiation
Creative Biolabs offers FZD5⁺ MSCs development services. The strategic manipulation of mesenchymal stem cells (MSCs) holds considerable promise for regenerative medicine, particularly in the context of bone repair. Notably, the priming of MSCs with Wnt3a-conditioned media induces a significant upregulation of endogenous Frizzled-5 (FZD5) expression. This molecular alteration, in turn, substantially enhances their intrinsic osteogenic potential, as evidenced by a remarkable threefold increase in bone-forming capacity observed during in vitro analyses. Creative Biolabs has refined differentiation protocols that consistently yield MSC populations exhibiting greater than 95% FZD5 expression.
Exosome-Mediated FZD5 Antagonist Delivery
Creative Biolabs offers exosome-mediated FZD5 antagonist delivery services. The development of advanced delivery platforms for targeted therapeutics is paramount in oncology, particularly for notoriously intractable malignancies such as pancreatic ductal adenocarcinoma (PDAC). Creative Biolabs has pioneered exosome isolation and loading technologies that ensure consistent and efficient payload delivery. This controlled release mechanism is designed to specifically block Wnt-driven metastatic dissemination, a critical process in the progression of many aggressive cancers. The enhanced tumor penetration afforded by exosome delivery, coupled with the precise targeting of FZD5, collectively positions this strategy as a compelling therapeutic avenue.
Leverage Creative Biolabs' end-to-end solutions in vector design, gene editing, and cell line development to accelerate your FZD5-targeted programs. Our team provides tailored expertise in gene editing validation, AAV optimization, and CAR-T functional assays. to schedule a technical consultation and discover how our platforms can help de-risk your development pipeline.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
