shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(SPAM1-shRNA-Seq2)(CAT#: AdV-SI1507WQ)

This product is a SPAM1-shRNA encoding AdV, which is based on AdV-5 serotype with E1/E3 gene deleted. The SPAM1 gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. The expression of SPAM1-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.