shRNA Lentivirus (self-inactivating), pU6-(SNRNP70-shRNA-Seq3)(CAT#: LV-SI0013WQ)

This product is a SNRNP70-shRNA encoding Lentivirus, which is based on HIV-1 serotype. The protein encoded by SNRNP70 is the component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. Misregulation of this gene has been implicated in the mRNA splicing-major pathway. The expression of SNRNP70-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Retroviridae
Species Lentivirus
Serotype HIV-1
Backbone Lenti-SIN
Tropism Both nondividing and dividing cells
Insert SNRNP70-shRNA-Seq3
Related Target/Protein SNRNP70
Region CDS
TargetSeq GCGCCGTACATTCGAGAGTTT
NCBI RefSeq NM_003089
Alternative Names RPU1; Snp1; U1AP; U170K; U1RNP; RNPU1Z; SNRP70; U1-70K
Titer >1*10^10 GC/mL
Related Diseases Alzheimer's Disease, Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
Target Gene
Gene ID 6625
Uniprot ID P08621

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